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Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan

BACKGROUND: Diabetes mellitus is a global public health problem that is caused by the lack of insulin secretion (type 1) or resistance to its action (type 2). A low insulin-to-glucagon ratio predicts an increase in the serum levels of branched chain amino acids, a feature confirmed in several popula...

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Autores principales: Alfaqih, Mahmoud A., Abu-Khdair, Zaina, Saadeh, Rami, Saadeh, Nesreen, Al-Dwairi, Ahmed, Al-Shboul, Othman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Family Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166113/
https://www.ncbi.nlm.nih.gov/pubmed/30060645
http://dx.doi.org/10.4082/kjfm.17.0122
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author Alfaqih, Mahmoud A.
Abu-Khdair, Zaina
Saadeh, Rami
Saadeh, Nesreen
Al-Dwairi, Ahmed
Al-Shboul, Othman
author_facet Alfaqih, Mahmoud A.
Abu-Khdair, Zaina
Saadeh, Rami
Saadeh, Nesreen
Al-Dwairi, Ahmed
Al-Shboul, Othman
author_sort Alfaqih, Mahmoud A.
collection PubMed
description BACKGROUND: Diabetes mellitus is a global public health problem that is caused by the lack of insulin secretion (type 1) or resistance to its action (type 2). A low insulin-to-glucagon ratio predicts an increase in the serum levels of branched chain amino acids, a feature confirmed in several populations. This relationship has not been assessed in Jordan. The objective of this study was to investigate the association between serum branched chain amino acids and type 2 diabetes mellitus in patients in Jordan. METHODS: Two hundred type 2 diabetes mellitus patients and an additional 200 non-diabetic controls were recruited. Age, body mass index, and waist circumference of the subjects were recorded. Branched chain amino acid, total cholesterol, and triglyceride levels were measured from the collected serum samples. RESULTS: Serum branched chain amino acid levels were significantly higher in type 2 diabetes mellitus patients than in non-diabetes individuals (P<0.0001). In binomial regression analysis, serum branched chain amino acid levels remained significantly associated with diabetes mellitus and increased its risk (odds ratio, 1.004; 95% confidence interval, 1.001–1.006; P=0.003). CONCLUSION: Type 2 diabetes mellitus is associated with higher branched chain amino acid levels in Jordan independent of age, sex, body mass index, waist circumference, and total serum cholesterol and serum triglyceride levels.
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spelling pubmed-61661132018-10-04 Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan Alfaqih, Mahmoud A. Abu-Khdair, Zaina Saadeh, Rami Saadeh, Nesreen Al-Dwairi, Ahmed Al-Shboul, Othman Korean J Fam Med Original Article BACKGROUND: Diabetes mellitus is a global public health problem that is caused by the lack of insulin secretion (type 1) or resistance to its action (type 2). A low insulin-to-glucagon ratio predicts an increase in the serum levels of branched chain amino acids, a feature confirmed in several populations. This relationship has not been assessed in Jordan. The objective of this study was to investigate the association between serum branched chain amino acids and type 2 diabetes mellitus in patients in Jordan. METHODS: Two hundred type 2 diabetes mellitus patients and an additional 200 non-diabetic controls were recruited. Age, body mass index, and waist circumference of the subjects were recorded. Branched chain amino acid, total cholesterol, and triglyceride levels were measured from the collected serum samples. RESULTS: Serum branched chain amino acid levels were significantly higher in type 2 diabetes mellitus patients than in non-diabetes individuals (P<0.0001). In binomial regression analysis, serum branched chain amino acid levels remained significantly associated with diabetes mellitus and increased its risk (odds ratio, 1.004; 95% confidence interval, 1.001–1.006; P=0.003). CONCLUSION: Type 2 diabetes mellitus is associated with higher branched chain amino acid levels in Jordan independent of age, sex, body mass index, waist circumference, and total serum cholesterol and serum triglyceride levels. Korean Academy of Family Medicine 2018-09 2018-07-31 /pmc/articles/PMC6166113/ /pubmed/30060645 http://dx.doi.org/10.4082/kjfm.17.0122 Text en Copyright © 2018 The Korean Academy of Family Medicine This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Alfaqih, Mahmoud A.
Abu-Khdair, Zaina
Saadeh, Rami
Saadeh, Nesreen
Al-Dwairi, Ahmed
Al-Shboul, Othman
Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan
title Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan
title_full Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan
title_fullStr Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan
title_full_unstemmed Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan
title_short Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan
title_sort serum branched chain amino acids are associated with type 2 diabetes mellitus in jordan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166113/
https://www.ncbi.nlm.nih.gov/pubmed/30060645
http://dx.doi.org/10.4082/kjfm.17.0122
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