Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin

[Image: see text] Fentanyl and its derivatives have become pervasive contaminants in the U.S. heroin supply. Previously, we reported a proof-of-concept vaccine designed to combat against heroin contaminated with fentanyl. Herein, we optimized the admixture vaccine and found that it surpassed the ind...

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Autores principales: Hwang, Candy S., Smith, Lauren C., Natori, Yoshihiro, Ellis, Beverly, Zhou, Bin, Janda, Kim D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166218/
https://www.ncbi.nlm.nih.gov/pubmed/30288464
http://dx.doi.org/10.1021/acsomega.8b01478
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author Hwang, Candy S.
Smith, Lauren C.
Natori, Yoshihiro
Ellis, Beverly
Zhou, Bin
Janda, Kim D.
author_facet Hwang, Candy S.
Smith, Lauren C.
Natori, Yoshihiro
Ellis, Beverly
Zhou, Bin
Janda, Kim D.
author_sort Hwang, Candy S.
collection PubMed
description [Image: see text] Fentanyl and its derivatives have become pervasive contaminants in the U.S. heroin supply. Previously, we reported a proof-of-concept vaccine designed to combat against heroin contaminated with fentanyl. Herein, we optimized the admixture vaccine and found that it surpassed the individual vaccines in every antinociceptive test, including a 10% fentanyl to heroin formulation. It is anticipated that other co-occurring drug abuse disorders may also be examined with admixture vaccines.
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spelling pubmed-61662182018-10-02 Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin Hwang, Candy S. Smith, Lauren C. Natori, Yoshihiro Ellis, Beverly Zhou, Bin Janda, Kim D. ACS Omega [Image: see text] Fentanyl and its derivatives have become pervasive contaminants in the U.S. heroin supply. Previously, we reported a proof-of-concept vaccine designed to combat against heroin contaminated with fentanyl. Herein, we optimized the admixture vaccine and found that it surpassed the individual vaccines in every antinociceptive test, including a 10% fentanyl to heroin formulation. It is anticipated that other co-occurring drug abuse disorders may also be examined with admixture vaccines. American Chemical Society 2018-09-20 /pmc/articles/PMC6166218/ /pubmed/30288464 http://dx.doi.org/10.1021/acsomega.8b01478 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Hwang, Candy S.
Smith, Lauren C.
Natori, Yoshihiro
Ellis, Beverly
Zhou, Bin
Janda, Kim D.
Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin
title Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin
title_full Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin
title_fullStr Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin
title_full_unstemmed Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin
title_short Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin
title_sort improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: antinociceptive evaluation of fentanyl-contaminated heroin
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166218/
https://www.ncbi.nlm.nih.gov/pubmed/30288464
http://dx.doi.org/10.1021/acsomega.8b01478
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