Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells

Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent phenotype. Here, we demonstrate that the retinal pigment epithelium (RPE), essential for photoreceptor development and functio...

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Detalles Bibliográficos
Autores principales: May-Simera, Helen Louise, Wan, Qin, Jha, Balendu Shekhar, Hartford, Juliet, Khristov, Vladimir, Dejene, Roba, Chang, Justin, Patnaik, Sarita, Lu, Quanlong, Banerjee, Poulomi, Silver, Jason, Insinna-Kettenhofen, Christine, Patel, Dishita, Lotfi, Mostafa, Malicdan, May, Hotaling, Nathan, Maminishkis, Arvydas, Sridharan, Rupa, Brooks, Brian, Miyagishima, Kiyoharu, Gunay-Aygun, Meral, Pal, Rajarshi, Westlake, Christopher, Miller, Sheldon, Sharma, Ruchi, Bharti, Kapil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166245/
https://www.ncbi.nlm.nih.gov/pubmed/29298421
http://dx.doi.org/10.1016/j.celrep.2017.12.038

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