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Pathogenesis of medication-related osteonecrosis of the jaw: a comparative study of in vivo and in vitro trials
OBJECTIVE: This study was performed to determine whether the results of prevailing in vivo and in vitro studies offer a reliable model for investigation of medication-related osteonecrosis of the jaw (MRONJ). METHODS: Embase, Medline, and the Cochrane Library were searched for articles published fro...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166332/ https://www.ncbi.nlm.nih.gov/pubmed/30091399 http://dx.doi.org/10.1177/0300060518788987 |
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author | Holtmann, Henrik Lommen, Julian Kübler, Norbert R. Sproll, Christoph Rana, Majeed Karschuck, Patrick Depprich, Rita |
author_facet | Holtmann, Henrik Lommen, Julian Kübler, Norbert R. Sproll, Christoph Rana, Majeed Karschuck, Patrick Depprich, Rita |
author_sort | Holtmann, Henrik |
collection | PubMed |
description | OBJECTIVE: This study was performed to determine whether the results of prevailing in vivo and in vitro studies offer a reliable model for investigation of medication-related osteonecrosis of the jaw (MRONJ). METHODS: Embase, Medline, and the Cochrane Library were searched for articles published from September 2003 to June 2017 involving experimental approaches to the pathogenesis of MRONJ. In vivo and in vitro trials were analyzed with respect to the scientific question, study design, methodology, and results. RESULTS: Of 139 studies, 87, 46, and 6 conducted in vivo, in vitro, and both in vivo and in vitro experiments, respectively. Rats, mice, dogs, minipigs, sheep, and rabbits were the preferred animal models used. Osteoblasts, osteoclasts, fibroblasts, keratinocytes, macrophages, and human umbilical vein endothelial cells were the preferred cell types. Zoledronate, alendronate, ibandronate, and risedronate were the most frequent bisphosphonates used. MRONJ was most reliably induced in minipigs because of the close relationship with human bone physiology. In vitro studies showed that reduced viability, growth, and migration of cells in the bone and soft tissues were causative for MRONJ. Other than exposed jawbone after tooth extraction, no reliable cofactors were found. CONCLUSION: The minipig is the most suitable animal model for MRONJ. |
format | Online Article Text |
id | pubmed-6166332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-61663322018-10-03 Pathogenesis of medication-related osteonecrosis of the jaw: a comparative study of in vivo and in vitro trials Holtmann, Henrik Lommen, Julian Kübler, Norbert R. Sproll, Christoph Rana, Majeed Karschuck, Patrick Depprich, Rita J Int Med Res Pre-Clinical Research Reports OBJECTIVE: This study was performed to determine whether the results of prevailing in vivo and in vitro studies offer a reliable model for investigation of medication-related osteonecrosis of the jaw (MRONJ). METHODS: Embase, Medline, and the Cochrane Library were searched for articles published from September 2003 to June 2017 involving experimental approaches to the pathogenesis of MRONJ. In vivo and in vitro trials were analyzed with respect to the scientific question, study design, methodology, and results. RESULTS: Of 139 studies, 87, 46, and 6 conducted in vivo, in vitro, and both in vivo and in vitro experiments, respectively. Rats, mice, dogs, minipigs, sheep, and rabbits were the preferred animal models used. Osteoblasts, osteoclasts, fibroblasts, keratinocytes, macrophages, and human umbilical vein endothelial cells were the preferred cell types. Zoledronate, alendronate, ibandronate, and risedronate were the most frequent bisphosphonates used. MRONJ was most reliably induced in minipigs because of the close relationship with human bone physiology. In vitro studies showed that reduced viability, growth, and migration of cells in the bone and soft tissues were causative for MRONJ. Other than exposed jawbone after tooth extraction, no reliable cofactors were found. CONCLUSION: The minipig is the most suitable animal model for MRONJ. SAGE Publications 2018-08-09 2018-10 /pmc/articles/PMC6166332/ /pubmed/30091399 http://dx.doi.org/10.1177/0300060518788987 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Pre-Clinical Research Reports Holtmann, Henrik Lommen, Julian Kübler, Norbert R. Sproll, Christoph Rana, Majeed Karschuck, Patrick Depprich, Rita Pathogenesis of medication-related osteonecrosis of the jaw: a comparative study of in vivo and in vitro trials |
title | Pathogenesis of medication-related osteonecrosis of the jaw: a
comparative study of in vivo and in vitro
trials |
title_full | Pathogenesis of medication-related osteonecrosis of the jaw: a
comparative study of in vivo and in vitro
trials |
title_fullStr | Pathogenesis of medication-related osteonecrosis of the jaw: a
comparative study of in vivo and in vitro
trials |
title_full_unstemmed | Pathogenesis of medication-related osteonecrosis of the jaw: a
comparative study of in vivo and in vitro
trials |
title_short | Pathogenesis of medication-related osteonecrosis of the jaw: a
comparative study of in vivo and in vitro
trials |
title_sort | pathogenesis of medication-related osteonecrosis of the jaw: a
comparative study of in vivo and in vitro
trials |
topic | Pre-Clinical Research Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166332/ https://www.ncbi.nlm.nih.gov/pubmed/30091399 http://dx.doi.org/10.1177/0300060518788987 |
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