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Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China

Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC). Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigen...

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Autores principales: Meng, Hong-xue, Miao, Su-sheng, Chen, Kexin, Li, Hui-ning, Yao, Guodong, Geng, Jiashi, Wang, Hongmei, Shi, Qing-tao, He, Jing, Mao, Xionghui, Tong, Fang-jia, Wei, Lan-Lan, Sun, Ji, Tan, Dongfeng, You, Qi, Li, Xiaomei, Geng, Jing-shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166388/
https://www.ncbi.nlm.nih.gov/pubmed/30310820
http://dx.doi.org/10.1155/2018/9594568
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author Meng, Hong-xue
Miao, Su-sheng
Chen, Kexin
Li, Hui-ning
Yao, Guodong
Geng, Jiashi
Wang, Hongmei
Shi, Qing-tao
He, Jing
Mao, Xionghui
Tong, Fang-jia
Wei, Lan-Lan
Sun, Ji
Tan, Dongfeng
You, Qi
Li, Xiaomei
Geng, Jing-shu
author_facet Meng, Hong-xue
Miao, Su-sheng
Chen, Kexin
Li, Hui-ning
Yao, Guodong
Geng, Jiashi
Wang, Hongmei
Shi, Qing-tao
He, Jing
Mao, Xionghui
Tong, Fang-jia
Wei, Lan-Lan
Sun, Ji
Tan, Dongfeng
You, Qi
Li, Xiaomei
Geng, Jing-shu
author_sort Meng, Hong-xue
collection PubMed
description Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC). Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigenesis and progression of OPSCC. Specimens from 1470 OPSCC patients collected from 2000 to 2016 were analyzed using the status of HPV by polymerase chain reaction (PCR) and p16 immunohistochemistry. Overexpression of p16 was observed in 81 (5.51%) of the 1470 cases, and HPV positive was present in 78 cases (5.31%) of the 1470 cases. HPV positive and p16 overexpression have a good concordance. However, we found that the etiological fraction of HPV in cancers of the OPSCCs was obviously lower in Northeast China than other cohorts previously reported. Interestingly, nearly 89% of patients with p16 expression were smokers, and nearly 70% of patients with p16 expression had a history of alcohol. Our study also demonstrates that p16 expression is significantly associated with early stage primary OPSCCs and the patients with p16 expression tend to show better survival following surgery and radiotherapy.
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spelling pubmed-61663882018-10-11 Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China Meng, Hong-xue Miao, Su-sheng Chen, Kexin Li, Hui-ning Yao, Guodong Geng, Jiashi Wang, Hongmei Shi, Qing-tao He, Jing Mao, Xionghui Tong, Fang-jia Wei, Lan-Lan Sun, Ji Tan, Dongfeng You, Qi Li, Xiaomei Geng, Jing-shu Biomed Res Int Research Article Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC). Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigenesis and progression of OPSCC. Specimens from 1470 OPSCC patients collected from 2000 to 2016 were analyzed using the status of HPV by polymerase chain reaction (PCR) and p16 immunohistochemistry. Overexpression of p16 was observed in 81 (5.51%) of the 1470 cases, and HPV positive was present in 78 cases (5.31%) of the 1470 cases. HPV positive and p16 overexpression have a good concordance. However, we found that the etiological fraction of HPV in cancers of the OPSCCs was obviously lower in Northeast China than other cohorts previously reported. Interestingly, nearly 89% of patients with p16 expression were smokers, and nearly 70% of patients with p16 expression had a history of alcohol. Our study also demonstrates that p16 expression is significantly associated with early stage primary OPSCCs and the patients with p16 expression tend to show better survival following surgery and radiotherapy. Hindawi 2018-09-17 /pmc/articles/PMC6166388/ /pubmed/30310820 http://dx.doi.org/10.1155/2018/9594568 Text en Copyright © 2018 Hong-xue Meng et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Meng, Hong-xue
Miao, Su-sheng
Chen, Kexin
Li, Hui-ning
Yao, Guodong
Geng, Jiashi
Wang, Hongmei
Shi, Qing-tao
He, Jing
Mao, Xionghui
Tong, Fang-jia
Wei, Lan-Lan
Sun, Ji
Tan, Dongfeng
You, Qi
Li, Xiaomei
Geng, Jing-shu
Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China
title Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China
title_full Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China
title_fullStr Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China
title_full_unstemmed Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China
title_short Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China
title_sort association of p16 as prognostic factors for oropharyngeal cancer: evaluation of p16 in 1470 patients for a 16 year study in northeast china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166388/
https://www.ncbi.nlm.nih.gov/pubmed/30310820
http://dx.doi.org/10.1155/2018/9594568
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