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Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region

Wiskott–Aldrich syndrome protein (WASP) activates the actin-related protein 2/3 homolog (Arp2/3) complex and regulates actin polymerization in a physiological setting. Cell division cycle 42 (Cdc42) is a key activator of WASP, which binds Cdc42 through a Cdc42/Rac-interactive binding (CRIB)-containi...

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Detalles Bibliográficos
Autores principales:	Tetley, George J. N., Szeto, Aydan, Fountain, Adam J., Mott, Helen R., Owen, Darerca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166713/ https://www.ncbi.nlm.nih.gov/pubmed/30104412 http://dx.doi.org/10.1074/jbc.RA118.003290

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