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Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling

Toll-like receptors (TLRs) form part of the host innate immune system, in which they act as sensors of microbial and endogenous danger signals. Upon TLR activation, the intracellular Toll/interleukin-1 receptor domains of TLR dimers initiate oligomerization of a multiprotein signaling platform compr...

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Detalles Bibliográficos
Autores principales:	De Nardo, Dominic, Balka, Katherine R., Cardona Gloria, Yamel, Rao, Vikram R., Latz, Eicke, Masters, Seth L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166714/ https://www.ncbi.nlm.nih.gov/pubmed/30076215 http://dx.doi.org/10.1074/jbc.RA118.003314

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