Mutually inhibitory Ras-PI(3,4)P(2) feedback loops mediate cell migration

Signal transduction and cytoskeleton networks in a wide variety of cells display excitability, but the mechanisms are poorly understood. Here, we show that during random migration and in response to chemoattractants, cells maintain complementary spatial and temporal distributions of Ras activity and...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xiaoguang, Edwards, Marc, Swaney, Kristen F., Singh, Nilmani, Bhattacharya, Sayak, Borleis, Jane, Long, Yu, Iglesias, Pablo A., Chen, Jie, Devreotes, Peter N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166812/
https://www.ncbi.nlm.nih.gov/pubmed/30194235
http://dx.doi.org/10.1073/pnas.1809039115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166812/
https://www.ncbi.nlm.nih.gov/pubmed/30194235
http://dx.doi.org/10.1073/pnas.1809039115

Ejemplares similares