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Mutually inhibitory Ras-PI(3,4)P(2) feedback loops mediate cell migration

Signal transduction and cytoskeleton networks in a wide variety of cells display excitability, but the mechanisms are poorly understood. Here, we show that during random migration and in response to chemoattractants, cells maintain complementary spatial and temporal distributions of Ras activity and...

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Detalles Bibliográficos
Autores principales:	Li, Xiaoguang, Edwards, Marc, Swaney, Kristen F., Singh, Nilmani, Bhattacharya, Sayak, Borleis, Jane, Long, Yu, Iglesias, Pablo A., Chen, Jie, Devreotes, Peter N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166812/ https://www.ncbi.nlm.nih.gov/pubmed/30194235 http://dx.doi.org/10.1073/pnas.1809039115

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