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A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia
A model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Gr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166954/ https://www.ncbi.nlm.nih.gov/pubmed/30273383 http://dx.doi.org/10.1371/journal.pone.0204393 |
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author | Jäkel, Frank Worm, Oliver Lange, Sascha Mertelsmann, Roland |
author_facet | Jäkel, Frank Worm, Oliver Lange, Sascha Mertelsmann, Roland |
author_sort | Jäkel, Frank |
collection | PubMed |
description | A model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Growth factors regulate the proliferation of cells dependent on the current demand. We provide a steady state analysis of the model and rough parameter estimates. Furthermore, we extend the model to include mutations that alter the replicative capacity of cells and introduce differentiation blocks. With these mutations the model develops signs of acute myeloid leukemia. |
format | Online Article Text |
id | pubmed-6166954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-61669542018-10-19 A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia Jäkel, Frank Worm, Oliver Lange, Sascha Mertelsmann, Roland PLoS One Research Article A model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Growth factors regulate the proliferation of cells dependent on the current demand. We provide a steady state analysis of the model and rough parameter estimates. Furthermore, we extend the model to include mutations that alter the replicative capacity of cells and introduce differentiation blocks. With these mutations the model develops signs of acute myeloid leukemia. Public Library of Science 2018-10-01 /pmc/articles/PMC6166954/ /pubmed/30273383 http://dx.doi.org/10.1371/journal.pone.0204393 Text en © 2018 Jäkel et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Jäkel, Frank Worm, Oliver Lange, Sascha Mertelsmann, Roland A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia |
title | A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia |
title_full | A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia |
title_fullStr | A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia |
title_full_unstemmed | A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia |
title_short | A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia |
title_sort | stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166954/ https://www.ncbi.nlm.nih.gov/pubmed/30273383 http://dx.doi.org/10.1371/journal.pone.0204393 |
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