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Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art
Introduction: The skin acts as a barrier and prevents transcutaneous delivery of therapeutic agents. Transfersomes are novel vesicular systems that are several times more elastic than other vesicular systems. These are composed of edge activator, phospholipids, ethanol, and sodium cholate and are ap...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167026/ https://www.ncbi.nlm.nih.gov/pubmed/30410704 http://dx.doi.org/10.1080/20022727.2017.1325708 |
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author | Rai, Shubhra Pandey, Vikas Rai, Gopal |
author_facet | Rai, Shubhra Pandey, Vikas Rai, Gopal |
author_sort | Rai, Shubhra |
collection | PubMed |
description | Introduction: The skin acts as a barrier and prevents transcutaneous delivery of therapeutic agents. Transfersomes are novel vesicular systems that are several times more elastic than other vesicular systems. These are composed of edge activator, phospholipids, ethanol, and sodium cholate and are applied in a non-occlusive manner. Areas covered: This article covers information such as merits/demerits of transfersomes, regulatory aspects of materials used in preparation, different methods of preparation, mechanism of action, review of clinical investigations performed, marketed preparations available, research reports, and patent reports related to transfersomes. Expert opinion: Research over the past few years has provided a better understanding of transfersomal permeation of therapeutic agents across stratum corneum barrier. Transfersomes provides an essential feature of their application to variety of compositions in order to optimize the permeability of a range of therapeutic molecules. This is evidenced by the fact that there are several Transfersome products being processed in advanced clinical trials. It is noteworthy that a number of Transfersome products for dermal and transdermal delivery will gain a global market success in near future. |
format | Online Article Text |
id | pubmed-6167026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-61670262018-10-02 Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art Rai, Shubhra Pandey, Vikas Rai, Gopal Nano Rev Exp Review Introduction: The skin acts as a barrier and prevents transcutaneous delivery of therapeutic agents. Transfersomes are novel vesicular systems that are several times more elastic than other vesicular systems. These are composed of edge activator, phospholipids, ethanol, and sodium cholate and are applied in a non-occlusive manner. Areas covered: This article covers information such as merits/demerits of transfersomes, regulatory aspects of materials used in preparation, different methods of preparation, mechanism of action, review of clinical investigations performed, marketed preparations available, research reports, and patent reports related to transfersomes. Expert opinion: Research over the past few years has provided a better understanding of transfersomal permeation of therapeutic agents across stratum corneum barrier. Transfersomes provides an essential feature of their application to variety of compositions in order to optimize the permeability of a range of therapeutic molecules. This is evidenced by the fact that there are several Transfersome products being processed in advanced clinical trials. It is noteworthy that a number of Transfersome products for dermal and transdermal delivery will gain a global market success in near future. Taylor & Francis 2017-06-07 /pmc/articles/PMC6167026/ /pubmed/30410704 http://dx.doi.org/10.1080/20022727.2017.1325708 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Rai, Shubhra Pandey, Vikas Rai, Gopal Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art |
title | Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art |
title_full | Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art |
title_fullStr | Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art |
title_full_unstemmed | Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art |
title_short | Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art |
title_sort | transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167026/ https://www.ncbi.nlm.nih.gov/pubmed/30410704 http://dx.doi.org/10.1080/20022727.2017.1325708 |
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