Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of KCNJ10, which encodes the inward-rectifying potassium channel KIR4.1, causes seizures and progressive neurological decline. We investigated Kir4.1 fun...

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Detalles Bibliográficos
Autores principales: Schirmer, Lucas, Möbius, Wiebke, Zhao, Chao, Cruz-Herranz, Andrés, Ben Haim, Lucile, Cordano, Christian, Shiow, Lawrence R, Kelley, Kevin W, Sadowski, Boguslawa, Timmons, Garrett, Pröbstel, Anne-Katrin, Wright, Jackie N, Sin, Jung Hyung, Devereux, Michael, Morrison, Daniel E, Chang, Sandra M, Sabeur, Khalida, Green, Ari J, Nave, Klaus-Armin, Franklin, Robin JM, Rowitch, David H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167053/
https://www.ncbi.nlm.nih.gov/pubmed/30204081
http://dx.doi.org/10.7554/eLife.36428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167053/
https://www.ncbi.nlm.nih.gov/pubmed/30204081
http://dx.doi.org/10.7554/eLife.36428

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