Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report

We report the case of a woman with chronic hepatitis C and idiopathic thrombocytopenic purpura (ITP) who developed autoimmune hepatitis (AIH) during antiviral therapy with ledipasvir (LDV)/sofosbuvir (SOF). The onset of acute hepatitis rose two weeks after starting treatment with LDV/SOF when HCV‐RN...

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Autores principales: Covini, Giovanni, Bredi, Elena, Badalamenti, Salvatore, Roncalli, Massimo, Aghemo, Alessio, Colombo, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167068/
https://www.ncbi.nlm.nih.gov/pubmed/30288473
http://dx.doi.org/10.1002/hep4.1248
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author Covini, Giovanni
Bredi, Elena
Badalamenti, Salvatore
Roncalli, Massimo
Aghemo, Alessio
Colombo, Massimo
author_facet Covini, Giovanni
Bredi, Elena
Badalamenti, Salvatore
Roncalli, Massimo
Aghemo, Alessio
Colombo, Massimo
author_sort Covini, Giovanni
collection PubMed
description We report the case of a woman with chronic hepatitis C and idiopathic thrombocytopenic purpura (ITP) who developed autoimmune hepatitis (AIH) during antiviral therapy with ledipasvir (LDV)/sofosbuvir (SOF). The onset of acute hepatitis rose two weeks after starting treatment with LDV/SOF when HCV‐RNA tested negative, suggesting a link between rapid HCV clearance and de novo autoimmune diseases. Conclusion: This case report proposes new immunologic scenarios in patients with hepatitis C virus (HCV) with laboratory or clinical signs of autoimmunity during direct‐acting antiviral (DAA) therapy.
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spelling pubmed-61670682018-10-04 Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report Covini, Giovanni Bredi, Elena Badalamenti, Salvatore Roncalli, Massimo Aghemo, Alessio Colombo, Massimo Hepatol Commun Brief Reports We report the case of a woman with chronic hepatitis C and idiopathic thrombocytopenic purpura (ITP) who developed autoimmune hepatitis (AIH) during antiviral therapy with ledipasvir (LDV)/sofosbuvir (SOF). The onset of acute hepatitis rose two weeks after starting treatment with LDV/SOF when HCV‐RNA tested negative, suggesting a link between rapid HCV clearance and de novo autoimmune diseases. Conclusion: This case report proposes new immunologic scenarios in patients with hepatitis C virus (HCV) with laboratory or clinical signs of autoimmunity during direct‐acting antiviral (DAA) therapy. John Wiley and Sons Inc. 2018-09-25 /pmc/articles/PMC6167068/ /pubmed/30288473 http://dx.doi.org/10.1002/hep4.1248 Text en © 2018 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Reports
Covini, Giovanni
Bredi, Elena
Badalamenti, Salvatore
Roncalli, Massimo
Aghemo, Alessio
Colombo, Massimo
Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report
title Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report
title_full Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report
title_fullStr Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report
title_full_unstemmed Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report
title_short Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report
title_sort autoimmune hepatitis during ledipasvir/sofosbuvir treatment of hepatitis c: a case report
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167068/
https://www.ncbi.nlm.nih.gov/pubmed/30288473
http://dx.doi.org/10.1002/hep4.1248
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