Correcting the Mean-Variance Dependency for Differential Variability Testing Using Single-Cell RNA Sequencing Data

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Cell-to-cell transcriptional variability in otherwise homogeneous cell populations plays an important role in tissue function and development. Single-cell RNA sequencing can characterize this variability in a transcriptome-wide manner. However, technical variation and the confounding between variabi...

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Detalles Bibliográficos
Autores principales: Eling, Nils, Richard, Arianne C., Richardson, Sylvia, Marioni, John C., Vallejos, Catalina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167088/
https://www.ncbi.nlm.nih.gov/pubmed/30172840
http://dx.doi.org/10.1016/j.cels.2018.06.011
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