Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Selective disruption of synaptic drive to inhibitory neurons could contribute to the pathophysiology of various brain disorders. We have previously identified a GluN2A-selective positive allosteric modulator, GNE-8324, that selectively enhances N-methyl-d-aspartate receptor (NMDAR)-mediated synaptic...

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Detalles Bibliográficos
Autores principales: Yao, Lulu, Grand, Teddy, Hanson, Jesse E., Paoletti, Pierre, Zhou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167324/
https://www.ncbi.nlm.nih.gov/pubmed/30275542
http://dx.doi.org/10.1038/s41467-018-06512-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167324/
https://www.ncbi.nlm.nih.gov/pubmed/30275542
http://dx.doi.org/10.1038/s41467-018-06512-7

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