Outward open conformation of a Major Facilitator Superfamily multidrug/H(+) antiporter provides insights into switching mechanism

Multidrug resistance (MDR) poses a major challenge to medicine. A principle cause of MDR is through active efflux by MDR transporters situated in the bacterial membrane. Here we present the crystal structure of the major facilitator superfamily (MFS) drug/H(+) antiporter MdfA from Escherichia coli i...

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Detalles Bibliográficos
Autores principales: Nagarathinam, Kumar, Nakada-Nakura, Yoshiko, Parthier, Christoph, Terada, Tohru, Juge, Narinobu, Jaenecke, Frank, Liu, Kehong, Hotta, Yunhon, Miyaji, Takaaki, Omote, Hiroshi, Iwata, So, Nomura, Norimichi, Stubbs, Milton T., Tanabe, Mikio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167325/
https://www.ncbi.nlm.nih.gov/pubmed/30275448
http://dx.doi.org/10.1038/s41467-018-06306-x

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