The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity

The de novo design of integral membrane proteins remains a major challenge in protein chemistry. Here, we describe the bottom-up design of a genetically-encoded synthetic membrane protein comprising only four amino acids (L, S, G and W) in the transmembrane domains. This artificial sequence, which w...

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Detalles Bibliográficos
Autores principales: Lalaurie, Christophe J., Dufour, Virginie, Meletiou, Anna, Ratcliffe, Sarah, Harland, Abigail, Wilson, Olivia, Vamasiri, Chiratchaya, Shoemark, Deborah K., Williams, Christopher, Arthur, Christopher J., Sessions, Richard B., Crump, Matthew P., Anderson, J. L. Ross, Curnow, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167376/
https://www.ncbi.nlm.nih.gov/pubmed/30275547
http://dx.doi.org/10.1038/s41598-018-31964-8

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