Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study

Patients with steroid refractory gastrointestinal (GI) tract graft- vs.-host disease (GvHD) face a poor prognosis and limited therapeutic options. To accurately assess the efficacy and safety of fecal microbiota transplantation (FMT) in treating steroid refractory GI tract GvHD, we conducted a pilot...

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Autores principales: Qi, Xiaofei, Li, Xuewei, Zhao, Ye, Wu, Xiaojin, Chen, Feng, Ma, Xiao, Zhang, Faming, Wu, Depei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167440/
https://www.ncbi.nlm.nih.gov/pubmed/30319644
http://dx.doi.org/10.3389/fimmu.2018.02195
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author Qi, Xiaofei
Li, Xuewei
Zhao, Ye
Wu, Xiaojin
Chen, Feng
Ma, Xiao
Zhang, Faming
Wu, Depei
author_facet Qi, Xiaofei
Li, Xuewei
Zhao, Ye
Wu, Xiaojin
Chen, Feng
Ma, Xiao
Zhang, Faming
Wu, Depei
author_sort Qi, Xiaofei
collection PubMed
description Patients with steroid refractory gastrointestinal (GI) tract graft- vs.-host disease (GvHD) face a poor prognosis and limited therapeutic options. To accurately assess the efficacy and safety of fecal microbiota transplantation (FMT) in treating steroid refractory GI tract GvHD, we conducted a pilot study involving eight patients. Having received FMTs, all patients' clinical symptoms relieved, bacteria enriched, and microbiota composition reconstructed. Compared to those who did not receive FMT, these eight patients achieved a higher progression-free survival. FMT can serve as a therapeutic option for GI tract aGVHD, but its effectiveness and safety need further evaluations. Clinical Trial Registration: NCT03148743.
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spelling pubmed-61674402018-10-12 Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study Qi, Xiaofei Li, Xuewei Zhao, Ye Wu, Xiaojin Chen, Feng Ma, Xiao Zhang, Faming Wu, Depei Front Immunol Immunology Patients with steroid refractory gastrointestinal (GI) tract graft- vs.-host disease (GvHD) face a poor prognosis and limited therapeutic options. To accurately assess the efficacy and safety of fecal microbiota transplantation (FMT) in treating steroid refractory GI tract GvHD, we conducted a pilot study involving eight patients. Having received FMTs, all patients' clinical symptoms relieved, bacteria enriched, and microbiota composition reconstructed. Compared to those who did not receive FMT, these eight patients achieved a higher progression-free survival. FMT can serve as a therapeutic option for GI tract aGVHD, but its effectiveness and safety need further evaluations. Clinical Trial Registration: NCT03148743. Frontiers Media S.A. 2018-09-25 /pmc/articles/PMC6167440/ /pubmed/30319644 http://dx.doi.org/10.3389/fimmu.2018.02195 Text en Copyright © 2018 Qi, Li, Zhao, Wu, Chen, Ma, Zhang and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Qi, Xiaofei
Li, Xuewei
Zhao, Ye
Wu, Xiaojin
Chen, Feng
Ma, Xiao
Zhang, Faming
Wu, Depei
Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study
title Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study
title_full Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study
title_fullStr Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study
title_full_unstemmed Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study
title_short Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study
title_sort treating steroid refractory intestinal acute graft-vs.-host disease with fecal microbiota transplantation: a pilot study
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167440/
https://www.ncbi.nlm.nih.gov/pubmed/30319644
http://dx.doi.org/10.3389/fimmu.2018.02195
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