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Computational Insight Into Vitamin K(1) ω-Hydroxylation by Cytochrome P450 4F2
Vitamin K(1) (VK1) plays an important role in the modulation of bleeding disorders. It has been reported that ω-hydroxylation on the VK1 aliphatic chain is catalyzed by cytochrome P450 4F2 (CYP4F2), an enzyme responsible for the metabolism of eicosanoids. However, the mechanism of VK1 ω-hydroxylatio...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167488/ https://www.ncbi.nlm.nih.gov/pubmed/30319412 http://dx.doi.org/10.3389/fphar.2018.01065 |