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Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease
α-Synuclein (αS) is a conserved and abundant neuronal protein with unusual structural properties. It appears to partition between folded and unstructured states as well as between membrane-bound and aqueously soluble states. In addition, a switch between monomeric and tetrameric/multimeric states ha...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167557/ https://www.ncbi.nlm.nih.gov/pubmed/30319334 http://dx.doi.org/10.3389/fnins.2018.00623 |