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Photoreceptor Guanylate Cyclase (GUCY2D) Mutations Cause Retinal Dystrophies by Severe Malfunction of Ca(2+)-Dependent Cyclic GMP Synthesis
Over 100 mutations in GUCY2D that encodes the photoreceptor guanylate cyclase GC-E are known to cause two major diseases: autosomal recessive Leber congenital amaurosis (arLCA) or autosomal dominant cone-rod dystrophy (adCRD) with a poorly understood mechanism at the molecular level in most cases. O...
Autores principales: | Wimberg, Hanna, Lev, Dorit, Yosovich, Keren, Namburi, Prasanthi, Banin, Eyal, Sharon, Dror, Koch, Karl-Wilhelm |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167591/ https://www.ncbi.nlm.nih.gov/pubmed/30319355 http://dx.doi.org/10.3389/fnmol.2018.00348 |
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