Lorazepam as a Cause of Drug-Induced Liver Injury

Lorazepam is a benzodiazepine derivative that is globally used for the therapy of anxiety and insomnia. A 51-year-old Japanese man with yellowish discoloration of the eyes and skin and pruritus was admitted due to liver dysfunction. He had taken lorazepam approximately 5 months prior to this admissi...

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Autores principales: Arai, Toshio, Kogi, Kazutoyo, Honda, Yuki, Suzuki, Takao, Kawai, Koji, Okamoto, Masako, Fujioka, Takahiro, Murata, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167696/
https://www.ncbi.nlm.nih.gov/pubmed/30283291
http://dx.doi.org/10.1159/000492209
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author Arai, Toshio
Kogi, Kazutoyo
Honda, Yuki
Suzuki, Takao
Kawai, Koji
Okamoto, Masako
Fujioka, Takahiro
Murata, Nobuhiro
author_facet Arai, Toshio
Kogi, Kazutoyo
Honda, Yuki
Suzuki, Takao
Kawai, Koji
Okamoto, Masako
Fujioka, Takahiro
Murata, Nobuhiro
author_sort Arai, Toshio
collection PubMed
description Lorazepam is a benzodiazepine derivative that is globally used for the therapy of anxiety and insomnia. A 51-year-old Japanese man with yellowish discoloration of the eyes and skin and pruritus was admitted due to liver dysfunction. He had taken lorazepam approximately 5 months prior to this admission. The clinical presentation and pathologic findings in the liver were consistent with drug-induced liver injury. After cessation of lorazepam, treatment with Stronger neo-minophagen C and ursodeoxycholic acid was started, and his liver injury resolved after 59 days. This case must serve as a warning to physicians to be aware of the possibility of unexpected liver injury caused by lorazepam.
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spelling pubmed-61676962018-10-03 Lorazepam as a Cause of Drug-Induced Liver Injury Arai, Toshio Kogi, Kazutoyo Honda, Yuki Suzuki, Takao Kawai, Koji Okamoto, Masako Fujioka, Takahiro Murata, Nobuhiro Case Rep Gastroenterol Single Case Lorazepam is a benzodiazepine derivative that is globally used for the therapy of anxiety and insomnia. A 51-year-old Japanese man with yellowish discoloration of the eyes and skin and pruritus was admitted due to liver dysfunction. He had taken lorazepam approximately 5 months prior to this admission. The clinical presentation and pathologic findings in the liver were consistent with drug-induced liver injury. After cessation of lorazepam, treatment with Stronger neo-minophagen C and ursodeoxycholic acid was started, and his liver injury resolved after 59 days. This case must serve as a warning to physicians to be aware of the possibility of unexpected liver injury caused by lorazepam. S. Karger AG 2018-08-31 /pmc/articles/PMC6167696/ /pubmed/30283291 http://dx.doi.org/10.1159/000492209 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Arai, Toshio
Kogi, Kazutoyo
Honda, Yuki
Suzuki, Takao
Kawai, Koji
Okamoto, Masako
Fujioka, Takahiro
Murata, Nobuhiro
Lorazepam as a Cause of Drug-Induced Liver Injury
title Lorazepam as a Cause of Drug-Induced Liver Injury
title_full Lorazepam as a Cause of Drug-Induced Liver Injury
title_fullStr Lorazepam as a Cause of Drug-Induced Liver Injury
title_full_unstemmed Lorazepam as a Cause of Drug-Induced Liver Injury
title_short Lorazepam as a Cause of Drug-Induced Liver Injury
title_sort lorazepam as a cause of drug-induced liver injury
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167696/
https://www.ncbi.nlm.nih.gov/pubmed/30283291
http://dx.doi.org/10.1159/000492209
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