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Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

The HIV-1-envelope glycoprotein (Env) is the main target of antigen design for antibody-based prophylactic vaccines. The generation of broadly neutralizing antibodies (bNAb) likely requires the appropriate presentation of stabilized trimers preventing exposure of non-neutralizing antibody (nNAb) epi...

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Detalles Bibliográficos
Autores principales:	Aldon, Yoann, McKay, Paul F., Allen, Joel, Ozorowski, Gabriel, Felfödiné Lévai, Réka, Tolazzi, Monica, Rogers, Paul, He, Linling, de Val, Natalia, Fábián, Katalin, Scarlatti, Gabriella, Zhu, Jiang, Ward, Andrew B., Crispin, Max, Shattock, Robin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167709/ https://www.ncbi.nlm.nih.gov/pubmed/30232012 http://dx.doi.org/10.1016/j.celrep.2018.08.051

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