Metabolomics-Driven Elucidation of Cellular Nitrate Tolerance Reveals Ascorbic Acid Prevents Nitroglycerin-Induced Inactivation of Xanthine Oxidase

Glyceryl trinitrate (GTN) has found widespread use for the treatment of angina pectoris, a pathological condition manifested by chest pain resulting from insufficient blood supply to the heart. Metabolic conversion of GTN, a nitric oxide (NO) pro-drug, into NO induces vasodilation and improves blood...

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Detalles Bibliográficos
Autores principales: Axton, Elizabeth Rose, Cristobal, Eleonso, Choi, Jaewoo, Miranda, Cristobal L., Stevens, Jan Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167911/
https://www.ncbi.nlm.nih.gov/pubmed/30319419
http://dx.doi.org/10.3389/fphar.2018.01085

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