Cargando…
Otoacoustic Emissions for Outcome Prediction in Postanoxic Brain Injury
Background: Non-invasive, easy-to-use bedside tools to estimate prognosis in unresponsive patients with postanoxic brain injury are needed. We assessed the usefulness of otoacoustic emissions as outcome markers after cardiac arrest. Methods: Distortion product otoacoustic emissions (DPOAE) and trans...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167944/ https://www.ncbi.nlm.nih.gov/pubmed/30319528 http://dx.doi.org/10.3389/fneur.2018.00796 |
_version_ | 1783360289783152640 |
---|---|
author | Kondziella, Daniel Jensen, Anne Marie Hjuler, Thomas Bille, Michael Kjaergaard, Jesper |
author_facet | Kondziella, Daniel Jensen, Anne Marie Hjuler, Thomas Bille, Michael Kjaergaard, Jesper |
author_sort | Kondziella, Daniel |
collection | PubMed |
description | Background: Non-invasive, easy-to-use bedside tools to estimate prognosis in unresponsive patients with postanoxic brain injury are needed. We assessed the usefulness of otoacoustic emissions as outcome markers after cardiac arrest. Methods: Distortion product otoacoustic emissions (DPOAE) and transient evoked otoacoustic emissions (TEOAE) were measured in cardiac arrest patients whose prognosis was deemed to be poor following standard neurological assessment (n = 10). Ten patients with myocardial infarction without prior loss of consciousness served as controls. Results: Compared to controls with myocardial infarction, cardiac arrest patients with poor neurological prognosis had significantly less often preserved DPOAE (9.2 vs. 40.8% positive measurements; OR 0.15 (CI 0.07–0.30); p < 0.0001). Partially preserved DPOAE were noted in 4 cardiac arrest patients. TEOAE were not statistically different between the two groups. Conclusions: Despite their convenience, otoacoustic emissions cannot be used as reliable prognostic markers in cardiac arrest survivors. This is because we identified 4 cases with partially preserved otoacoustic emissions in a sample of 10 unresponsive post-cardiac arrest patients whose neurological condition was so poor that active treatment was withdrawn. However, we suggest that future research should address if decaying outer hair cell function over time may serve as a proxy for evolving ischemic brain damage. |
format | Online Article Text |
id | pubmed-6167944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61679442018-10-12 Otoacoustic Emissions for Outcome Prediction in Postanoxic Brain Injury Kondziella, Daniel Jensen, Anne Marie Hjuler, Thomas Bille, Michael Kjaergaard, Jesper Front Neurol Neurology Background: Non-invasive, easy-to-use bedside tools to estimate prognosis in unresponsive patients with postanoxic brain injury are needed. We assessed the usefulness of otoacoustic emissions as outcome markers after cardiac arrest. Methods: Distortion product otoacoustic emissions (DPOAE) and transient evoked otoacoustic emissions (TEOAE) were measured in cardiac arrest patients whose prognosis was deemed to be poor following standard neurological assessment (n = 10). Ten patients with myocardial infarction without prior loss of consciousness served as controls. Results: Compared to controls with myocardial infarction, cardiac arrest patients with poor neurological prognosis had significantly less often preserved DPOAE (9.2 vs. 40.8% positive measurements; OR 0.15 (CI 0.07–0.30); p < 0.0001). Partially preserved DPOAE were noted in 4 cardiac arrest patients. TEOAE were not statistically different between the two groups. Conclusions: Despite their convenience, otoacoustic emissions cannot be used as reliable prognostic markers in cardiac arrest survivors. This is because we identified 4 cases with partially preserved otoacoustic emissions in a sample of 10 unresponsive post-cardiac arrest patients whose neurological condition was so poor that active treatment was withdrawn. However, we suggest that future research should address if decaying outer hair cell function over time may serve as a proxy for evolving ischemic brain damage. Frontiers Media S.A. 2018-09-25 /pmc/articles/PMC6167944/ /pubmed/30319528 http://dx.doi.org/10.3389/fneur.2018.00796 Text en Copyright © 2018 Kondziella, Jensen, Hjuler, Bille and Kjaergaard. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Kondziella, Daniel Jensen, Anne Marie Hjuler, Thomas Bille, Michael Kjaergaard, Jesper Otoacoustic Emissions for Outcome Prediction in Postanoxic Brain Injury |
title | Otoacoustic Emissions for Outcome Prediction in Postanoxic Brain Injury |
title_full | Otoacoustic Emissions for Outcome Prediction in Postanoxic Brain Injury |
title_fullStr | Otoacoustic Emissions for Outcome Prediction in Postanoxic Brain Injury |
title_full_unstemmed | Otoacoustic Emissions for Outcome Prediction in Postanoxic Brain Injury |
title_short | Otoacoustic Emissions for Outcome Prediction in Postanoxic Brain Injury |
title_sort | otoacoustic emissions for outcome prediction in postanoxic brain injury |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167944/ https://www.ncbi.nlm.nih.gov/pubmed/30319528 http://dx.doi.org/10.3389/fneur.2018.00796 |
work_keys_str_mv | AT kondzielladaniel otoacousticemissionsforoutcomepredictioninpostanoxicbraininjury AT jensenannemarie otoacousticemissionsforoutcomepredictioninpostanoxicbraininjury AT hjulerthomas otoacousticemissionsforoutcomepredictioninpostanoxicbraininjury AT billemichael otoacousticemissionsforoutcomepredictioninpostanoxicbraininjury AT kjaergaardjesper otoacousticemissionsforoutcomepredictioninpostanoxicbraininjury |