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IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistance

BACKGROUND: Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling. Several polymorphisms in the IRS genes have been identified, but only the Gly to Arg 972 substitution of IRS-1 seems to have a pathogenic role in the development of type 2 diabetes mellitus (T2DM). Many po...

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Detalles Bibliográficos
Autores principales:	Yousef, Anas A, Behiry, Eman G, Allah, Wafaa M Abd, Hussien, Ahmed M, Abdelmoneam, Abdelmoneam A, Imam, Mahmoud H, Hikal, Doaa M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167972/ https://www.ncbi.nlm.nih.gov/pubmed/30319284 http://dx.doi.org/10.2147/TACG.S171096

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