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How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma

Rap proteins regulate liver physiopathology. For example, Rap2B promotes hepatocarcinoma (HCC) growth, while Rap1 might play a dual role. The RapGEF, Epac1, activates Rap upon cAMP binding, regulating metabolism, survival, and liver regeneration. A liver specific Epac2 isoform lacking cAMP-binding d...

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Detalles Bibliográficos
Autores principales:	Sequera, Celia, Manzano, Sara, Guerrero, Carmen, Porras, Almudena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Medicine Ltd 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168044/ https://www.ncbi.nlm.nih.gov/pubmed/30302196 http://dx.doi.org/10.2217/hep-2017-0026

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