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Aging alters the epigenetic asymmetry of HSC division

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control protein 42 (Cdc42). Here we demonstrate—using a compre...

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Detalles Bibliográficos
Autores principales:	Florian, M. Carolina, Klose, Markus, Sacma, Mehmet, Jablanovic, Jelena, Knudson, Luke, Nattamai, Kalpana J., Marka, Gina, Vollmer, Angelika, Soller, Karin, Sakk, Vadim, Cabezas-Wallscheid, Nina, Zheng, Yi, Mulaw, Medhanie A., Glauche, Ingmar, Geiger, Hartmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168157/ https://www.ncbi.nlm.nih.gov/pubmed/30235201 http://dx.doi.org/10.1371/journal.pbio.2003389

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