Cargando…

Visualization of the auditory pathway in rats with (18)F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation

Activation studies with positron emission tomography (PET) in auditory implant users explained some of the mechanisms underlying the variability of achieved speech comprehension. Since future developments of auditory implants will include studies in rodents, we aimed to inversely translate functiona...

Descripción completa

Detalles Bibliográficos
Autores principales: Mamach, Martin, Kessler, Mariella, Bankstahl, Jens P., Wilke, Florian, Geworski, Lilli, Bengel, Frank M., Kurt, Simone, Berding, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168174/
https://www.ncbi.nlm.nih.gov/pubmed/30278068
http://dx.doi.org/10.1371/journal.pone.0205044
_version_ 1783360324940857344
author Mamach, Martin
Kessler, Mariella
Bankstahl, Jens P.
Wilke, Florian
Geworski, Lilli
Bengel, Frank M.
Kurt, Simone
Berding, Georg
author_facet Mamach, Martin
Kessler, Mariella
Bankstahl, Jens P.
Wilke, Florian
Geworski, Lilli
Bengel, Frank M.
Kurt, Simone
Berding, Georg
author_sort Mamach, Martin
collection PubMed
description Activation studies with positron emission tomography (PET) in auditory implant users explained some of the mechanisms underlying the variability of achieved speech comprehension. Since future developments of auditory implants will include studies in rodents, we aimed to inversely translate functional PET imaging to rats. In normal hearing rats, activity in auditory and non-auditory regions was studied using (18)F-fluorodeoxyglucose ((18)F-FDG) PET with 3 different acoustic conditions: sound attenuated laboratory background, continuous white noise and rippled noise. Additionally, bilateral cochlea ablated animals were scanned. 3D image data were transferred into a stereotaxic standard space and evaluated using volume of interest (VOI) analyses and statistical parametric mapping (SPM). In normal hearing rats alongside the auditory pathway consistent activations of the nucleus cochlearis (NC), olivary complex (OC) and inferior colliculus (IC) were seen comparing stimuli with background. In this respect, no increased activation could be detected in the auditory cortex (AC), which even showed deactivation with white noise stimulation. Nevertheless, higher activity in the AC in normal hearing rats was observed for all 3 auditory conditions against the cochlea ablated status. Vice versa, in ablated status activity in the olfactory nucleus (ON) was higher compared to all auditory conditions in normal hearing rats. Our results indicate that activations can be demonstrated in normal hearing animals based on (18)F-FDG PET in nuclei along the central auditory pathway with different types of noise stimuli. However, in the AC missing activation with respect to the background advises the need for more rigorous background noise attenuation for non-invasive reference conditions. Finally, our data suggest cross-modal activation of the olfactory system following cochlea ablation–underlining, that (18)F-FDG PET appears to be well suited to study plasticity in rat models for cochlear implantation.
format Online
Article
Text
id pubmed-6168174
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-61681742018-10-19 Visualization of the auditory pathway in rats with (18)F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation Mamach, Martin Kessler, Mariella Bankstahl, Jens P. Wilke, Florian Geworski, Lilli Bengel, Frank M. Kurt, Simone Berding, Georg PLoS One Research Article Activation studies with positron emission tomography (PET) in auditory implant users explained some of the mechanisms underlying the variability of achieved speech comprehension. Since future developments of auditory implants will include studies in rodents, we aimed to inversely translate functional PET imaging to rats. In normal hearing rats, activity in auditory and non-auditory regions was studied using (18)F-fluorodeoxyglucose ((18)F-FDG) PET with 3 different acoustic conditions: sound attenuated laboratory background, continuous white noise and rippled noise. Additionally, bilateral cochlea ablated animals were scanned. 3D image data were transferred into a stereotaxic standard space and evaluated using volume of interest (VOI) analyses and statistical parametric mapping (SPM). In normal hearing rats alongside the auditory pathway consistent activations of the nucleus cochlearis (NC), olivary complex (OC) and inferior colliculus (IC) were seen comparing stimuli with background. In this respect, no increased activation could be detected in the auditory cortex (AC), which even showed deactivation with white noise stimulation. Nevertheless, higher activity in the AC in normal hearing rats was observed for all 3 auditory conditions against the cochlea ablated status. Vice versa, in ablated status activity in the olfactory nucleus (ON) was higher compared to all auditory conditions in normal hearing rats. Our results indicate that activations can be demonstrated in normal hearing animals based on (18)F-FDG PET in nuclei along the central auditory pathway with different types of noise stimuli. However, in the AC missing activation with respect to the background advises the need for more rigorous background noise attenuation for non-invasive reference conditions. Finally, our data suggest cross-modal activation of the olfactory system following cochlea ablation–underlining, that (18)F-FDG PET appears to be well suited to study plasticity in rat models for cochlear implantation. Public Library of Science 2018-10-02 /pmc/articles/PMC6168174/ /pubmed/30278068 http://dx.doi.org/10.1371/journal.pone.0205044 Text en © 2018 Mamach et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mamach, Martin
Kessler, Mariella
Bankstahl, Jens P.
Wilke, Florian
Geworski, Lilli
Bengel, Frank M.
Kurt, Simone
Berding, Georg
Visualization of the auditory pathway in rats with (18)F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation
title Visualization of the auditory pathway in rats with (18)F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation
title_full Visualization of the auditory pathway in rats with (18)F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation
title_fullStr Visualization of the auditory pathway in rats with (18)F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation
title_full_unstemmed Visualization of the auditory pathway in rats with (18)F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation
title_short Visualization of the auditory pathway in rats with (18)F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation
title_sort visualization of the auditory pathway in rats with (18)f-fdg pet activation studies based on different auditory stimuli and reference conditions including cochlea ablation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168174/
https://www.ncbi.nlm.nih.gov/pubmed/30278068
http://dx.doi.org/10.1371/journal.pone.0205044
work_keys_str_mv AT mamachmartin visualizationoftheauditorypathwayinratswith18ffdgpetactivationstudiesbasedondifferentauditorystimuliandreferenceconditionsincludingcochleaablation
AT kesslermariella visualizationoftheauditorypathwayinratswith18ffdgpetactivationstudiesbasedondifferentauditorystimuliandreferenceconditionsincludingcochleaablation
AT bankstahljensp visualizationoftheauditorypathwayinratswith18ffdgpetactivationstudiesbasedondifferentauditorystimuliandreferenceconditionsincludingcochleaablation
AT wilkeflorian visualizationoftheauditorypathwayinratswith18ffdgpetactivationstudiesbasedondifferentauditorystimuliandreferenceconditionsincludingcochleaablation
AT geworskililli visualizationoftheauditorypathwayinratswith18ffdgpetactivationstudiesbasedondifferentauditorystimuliandreferenceconditionsincludingcochleaablation
AT bengelfrankm visualizationoftheauditorypathwayinratswith18ffdgpetactivationstudiesbasedondifferentauditorystimuliandreferenceconditionsincludingcochleaablation
AT kurtsimone visualizationoftheauditorypathwayinratswith18ffdgpetactivationstudiesbasedondifferentauditorystimuliandreferenceconditionsincludingcochleaablation
AT berdinggeorg visualizationoftheauditorypathwayinratswith18ffdgpetactivationstudiesbasedondifferentauditorystimuliandreferenceconditionsincludingcochleaablation