Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel

C-type inactivation is a time-dependent process observed in many K(+) channels whereby prolonged activation by an external stimulus leads to a reduction in ionic conduction. While C-type inactivation is thought to be a result of a constriction of the selectivity filter, the local dynamics of the pro...

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Detalles Bibliográficos
Autores principales: Li, Jing, Ostmeyer, Jared, Cuello, Luis G., Perozo, Eduardo, Roux, Benoît
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168234/
https://www.ncbi.nlm.nih.gov/pubmed/30072373
http://dx.doi.org/10.1085/jgp.201812082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168234/
https://www.ncbi.nlm.nih.gov/pubmed/30072373
http://dx.doi.org/10.1085/jgp.201812082

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