Cargando…

Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel

C-type inactivation is a time-dependent process observed in many K(+) channels whereby prolonged activation by an external stimulus leads to a reduction in ionic conduction. While C-type inactivation is thought to be a result of a constriction of the selectivity filter, the local dynamics of the pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jing, Ostmeyer, Jared, Cuello, Luis G., Perozo, Eduardo, Roux, Benoît
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168234/ https://www.ncbi.nlm.nih.gov/pubmed/30072373 http://dx.doi.org/10.1085/jgp.201812082

Ejemplares similares

Inactivation in the potassium channel KcsA()
por: Xu, Yunyao, et al.
Publicado: (2019)

Inactivation of the KcsA potassium channel explored with heterotetramers
por: Rotem, Dvir, et al.
Publicado: (2010)

A Quantitative Description of KcsA Gating II: Single-Channel Currents
por: Chakrapani, Sudha, et al.
Publicado: (2007)

Molecular Architecture of Full-Length KcsA : Role of Cytoplasmic Domains in Ion Permeation and Activation Gating
por: Cortes, D. Marien, et al.
Publicado: (2001)

Mechanism of activation at the selectivity filter of the KcsA K(+) channel
por: Heer, Florian T, et al.
Publicado: (2017)

Importance of Hydration and Dynamics on the Selectivity of the KcsA and NaK Channels
por: Noskov, Sergei Yu., et al.
Publicado: (2007)

Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels
por: Noskov, Sergei Yu., et al.
Publicado: (2011)

Multiple Binding Sites for Fatty Acids on the Potassium Channel KcsA
por: Bolivar, Juan H., et al.
Publicado: (2012)

Intermolecular functional coupling between phosphoinositides and the potassium channel KcsA
por: Kiya, Takunari, et al.
Publicado: (2022)

A Quantitative Description of KcsA Gating I: Macroscopic Currents
por: Chakrapani, Sudha, et al.
Publicado: (2007)

Barium blockade of the KcsA channel in open and closed conformation datasets
por: Rohaim, Ahmed, et al.
Publicado: (2020)

Conformational Dynamics at the Inner Gate of KcsA during Activation
por: Hulse, Raymond E., et al.
Publicado: (2014)

Potassium-selective block of barium permeation through single KcsA channels
por: Piasta, Kene N., et al.
Publicado: (2011)

Characterizing the Fatty Acid Binding Site in the Cavity of Potassium Channel KcsA
por: Smithers, Natalie, et al.
Publicado: (2012)

Probing the Energy Landscape of Activation Gating of the Bacterial Potassium Channel KcsA
por: Linder, Tobias, et al.
Publicado: (2013)

Molecular interactions involved in proton-dependent gating in KcsA potassium channels
por: Posson, David J., et al.
Publicado: (2013)

Accessibility of Cations to the Selectivity Filter of KcsA in the Inactivated State: An Equilibrium Binding Study
por: Giudici, Ana Marcela, et al.
Publicado: (2019)

Detection of the Opening of the Bundle Crossing in KcsA with Fluorescence Lifetime Spectroscopy Reveals the Existence of Two Gates for Ion Conduction
por: Blunck, Rikard, et al.
Publicado: (2006)

The influence of membrane bilayer thickness on KcsA channel activity
por: Callahan, Karen M., et al.
Publicado: (2019)

The Role of Phosphatidic Acid and Cardiolipin in Stability of the Tetrameric Assembly of Potassium Channel KcsA
por: Raja, Mobeen
Publicado: (2010)

Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles
por: Kim, Dorothy M., et al.
Publicado: (2016)

Thermodynamics of ion selectivity in the KcsA K(+) channel
por: Dixit, Purushottam D., et al.
Publicado: (2011)

Anionic Phospholipids Shift the Conformational Equilibrium of the Selectivity Filter in the KcsA Channel to the Conductive Conformation: Predicted Consequences on Inactivation
por: Renart, María Lourdes, et al.
Publicado: (2023)

Conformational plasticity in the KcsA potassium channel pore helix revealed by homo-FRET studies
por: Renart, M. Lourdes, et al.
Publicado: (2019)

Dynamic water patterns change the stability of the collapsed filter conformation of the KcsA K(+) channel
por: Wu, Di
Publicado: (2017)

Recovery from Slow Inactivation in K(+) Channels is Controlled by Water Molecules
por: Ostmeyer, Jared, et al.
Publicado: (2013)

A computational study of barium blockades in the KcsA potassium channel based on multi-ion potential of mean force calculations and free energy perturbation
por: Rowley, Christopher N., et al.
Publicado: (2013)

The Open Gate Structure of the Membrane-Embedded KcsA Potassium Channel Viewed From the Cytoplasmic Side
por: Sumino, Ayumi, et al.
Publicado: (2013)

A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V
por: Rohaim, Ahmed, et al.
Publicado: (2022)

Non-Equilibrium Dynamics Contribute to Ion Selectivity in the KcsA Channel
por: Ngo, Van, et al.
Publicado: (2014)

Regulation of Ion Permeation of the KcsA Channel by Applied Midinfrared Field
por: Wang, Yize, et al.
Publicado: (2022)

Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations
por: Pan, Albert C., et al.
Publicado: (2011)

Unraveling of a Strongly Correlated Dynamical Network of Residues Controlling the Permeation of Potassium in KcsA Ion Channel
por: Cosseddu, Salvatore M., et al.
Publicado: (2021)

Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA
por: Delemotte, Lucie
Publicado: (2018)

Probing the interaction of lipids with the non-annular binding sites of the potassium channel KcsA by magic-angle spinning NMR
por: Marius, Phedra, et al.
Publicado: (2012)

Kcsa: It's a Potassium Channel
por: LeMasurier, Meredith, et al.
Publicado: (2001)

Studying KcsA Channel Clustering Using Single Channel Voltage-Clamp Fluorescence Imaging*
por: McGuire, Hugo, et al.
Publicado: (2022)

The Role of Extramembranous Cytoplasmic Termini in Assembly and Stability of the Tetrameric K(+)-Channel KcsA
por: Raja, Mobeen
Publicado: (2010)

Biomimetic KcsA channels with ultra-selective K(+) transport for monovalent ion sieving
por: Xin, Weiwen, et al.
Publicado: (2022)

A Multi-Scale Approach to Model K(+) Permeation Through the KcsA Channel
por: Horng, T. L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rarj784ialdf5rpbghemogd6t8