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Four drug-sensitive subunits are required for maximal effect of a voltage sensor–targeted KCNQ opener

KCNQ2-5 (Kv7.2–Kv7.5) channels are strongly influenced by an emerging class of small-molecule channel activators. Retigabine is the prototypical KCNQ activator that is thought to bind within the pore. It requires the presence of a Trp side chain that is conserved among retigabine-sensitive channels...

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Detalles Bibliográficos
Autores principales:	Wang, Alice W., Yau, Michael C., Wang, Caroline K., Sharmin, Nazlee, Yang, Runying Y., Pless, Stephan A., Kurata, Harley T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168237/ https://www.ncbi.nlm.nih.gov/pubmed/30166313 http://dx.doi.org/10.1085/jgp.201812014

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