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Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits
The binding of STIM1 to Orai1 controls the opening of store-operated CRAC channels as well as their extremely high Ca(2+) selectivity. Although STIM1 dimers are known to bind directly to the cytosolic C termini of the six Orai1 subunits (SUs) that form the channel hexamer, the dependence of channel...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168240/ https://www.ncbi.nlm.nih.gov/pubmed/30120197 http://dx.doi.org/10.1085/jgp.201711985 |