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Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation

Cellular lipids determine membrane integrity and fluidity and are being increasingly recognized to influence immune responses. Cellular cholesterol requirements are fulfilled through biosynthesis and uptake programs. In an intricate pathway involving the lysosomal cholesterol transporter NPC1, the s...

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Detalles Bibliográficos
Autores principales:	de la Roche, Marianne, Hamilton, Claire, Mortensen, Rebecca, Jeyaprakash, A. Arockia, Ghosh, Sanjay, Anand, Paras K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168277/ https://www.ncbi.nlm.nih.gov/pubmed/30054450 http://dx.doi.org/10.1083/jcb.201709057

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