Activated ALK signals through the ERK–ETV5–RET pathway to drive neuroblastoma oncogenesis

Activating mutations of the ALK receptor occur in a subset of neuroblastoma tumors. We previously demonstrated that Alk mutations cooperate with MYCN overexpression to induce neuroblastoma in mice and identified Ret as being strongly upregulated in MYCN/Alk(mut) tumors. By a genetic approach in vivo...

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Detalles Bibliográficos
Autores principales: Lopez-Delisle, Lucille, Pierre-Eugène, Cécile, Louis-Brennetot, Caroline, Surdez, Didier, Raynal, Virginie, Baulande, Sylvain, Boeva, Valentina, Grossetête-Lalami, Sandrine, Combaret, Valérie, Peuchmaur, Michel, Delattre, Olivier, Janoueix-Lerosey, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168456/
https://www.ncbi.nlm.nih.gov/pubmed/29321660
http://dx.doi.org/10.1038/s41388-017-0039-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168456/
https://www.ncbi.nlm.nih.gov/pubmed/29321660
http://dx.doi.org/10.1038/s41388-017-0039-5

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