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Molecular architecture and regulation of BCL10-MALT1 filaments

The CARD11-BCL10-MALT1 (CBM) complex triggers the adaptive immune response in lymphocytes and lymphoma cells. CARD11/CARMA1 acts as a molecular seed inducing BCL10 filaments, but the integration of MALT1 and the assembly of a functional CBM complex has remained elusive. Using cryo-EM we solved the h...

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Detalles Bibliográficos
Autores principales:	Schlauderer, Florian, Seeholzer, Thomas, Desfosses, Ambroise, Gehring, Torben, Strauss, Mike, Hopfner, Karl-Peter, Gutsche, Irina, Krappmann, Daniel, Lammens, Katja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168461/ https://www.ncbi.nlm.nih.gov/pubmed/30279415 http://dx.doi.org/10.1038/s41467-018-06573-8

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