Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4

Abnormalities in epigenetic modifiers are emerging as driving events in prostate cancer (PCa). The histone methyltransferase KMT2D, a frequently aberrant epigenetic modifier in various tumors, has an undefined role in PCa. Moreover, little is known regarding KMT2D’s mutation in Chinese patients or i...

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Detalles Bibliográficos
Autores principales: Lv, Shidong, Ji, Liyan, Chen, Bin, Liu, Shuqiang, Lei, Chengyong, Liu, Xi, Qi, Xiaoxiao, Wang, Ying, Lai-Han Leung, Elaine, Wang, Hongyi, Zhang, Lin, Yu, Xiaoming, Liu, Zhongqiu, Wei, Qiang, Lu, Linlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168472/
https://www.ncbi.nlm.nih.gov/pubmed/29269867
http://dx.doi.org/10.1038/s41388-017-0026-x

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