Chromatin architecture changes and DNA replication fork collapse are critical features in cryopreserved cells that are differentially controlled by cryoprotectants

In this work, we shed new light on the highly debated issue of chromatin fragmentation in cryopreserved cells. Moreover, for the first time, we describe replicating cell-specific DNA damage and higher-order chromatin alterations after freezing and thawing. We identified DNA structural changes associ...

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Detalles Bibliográficos
Autores principales: Falk, Martin, Falková, Iva, Kopečná, Olga, Bačíková, Alena, Pagáčová, Eva, Šimek, Daniel, Golan, Martin, Kozubek, Stanislav, Pekarová, Michaela, Follett, Shelby E., Klejdus, Bořivoj, Elliott, K. Wade, Varga, Krisztina, Teplá, Olga, Kratochvílová, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168476/
https://www.ncbi.nlm.nih.gov/pubmed/30279538
http://dx.doi.org/10.1038/s41598-018-32939-5

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