Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Asthma accounts for 380,000 deaths a year. Carotid body denervation has been shown to have a profound effect on airway hyper-responsiveness in animal models but a mechanistic explanation is lacking. Here we demonstrate, using a rat model of asthma (OVA-sensitized), that carotid body activation durin...

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Detalles Bibliográficos
Autores principales: Jendzjowsky, Nicholas G., Roy, Arijit, Barioni, Nicole O., Kelly, Margaret M., Green, Francis H. Y., Wyatt, Christopher N., Pye, Richard L., Tenorio-Lopes, Luana, Wilson, Richard J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168495/
https://www.ncbi.nlm.nih.gov/pubmed/30279412
http://dx.doi.org/10.1038/s41467-018-06189-y

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