A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

Recent reports suggest that induced neurons (iNs), but not induced pluripotent stem cell (iPSC)-derived neurons, largely preserve age-associated traits. Here, we report on the extent of preserved epigenetic and transcriptional aging signatures in directly converted induced neural stem cells (iNSCs)....

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Detalles Bibliográficos
Autores principales: Sheng, Chao, Jungverdorben, Johannes, Wiethoff, Hendrik, Lin, Qiong, Flitsch, Lea J., Eckert, Daniela, Hebisch, Matthias, Fischer, Julia, Kesavan, Jaideep, Weykopf, Beatrice, Schneider, Linda, Holtkamp, Dominik, Beck, Heinz, Till, Andreas, Wüllner, Ullrich, Ziller, Michael J., Wagner, Wolfgang, Peitz, Michael, Brüstle, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168501/
https://www.ncbi.nlm.nih.gov/pubmed/30279449
http://dx.doi.org/10.1038/s41467-018-06398-5

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