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Paradoxical positive association of serum adiponectin with all-cause mortality based on body composition in Japanese haemodialysis patients
We have previously reported a paradoxical association of serum adiponectin with aortic calcification in haemodialysis patients. Because serum adiponectin is a nutritional marker, we examined the association between serum adiponectin and all-cause mortality based on body composition in haemodialysis...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168594/ https://www.ncbi.nlm.nih.gov/pubmed/30279489 http://dx.doi.org/10.1038/s41598-018-33011-y |
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author | Machiba, Yuri Inaba, Masaaki Mori, Katsuhito Kurajoh, Masafumi Nishide, Kozo Norimine, Kyoko Yamakawa, Tomoyuki Shoji, Shigeichi Okuno, Senji |
author_facet | Machiba, Yuri Inaba, Masaaki Mori, Katsuhito Kurajoh, Masafumi Nishide, Kozo Norimine, Kyoko Yamakawa, Tomoyuki Shoji, Shigeichi Okuno, Senji |
author_sort | Machiba, Yuri |
collection | PubMed |
description | We have previously reported a paradoxical association of serum adiponectin with aortic calcification in haemodialysis patients. Because serum adiponectin is a nutritional marker, we examined the association between serum adiponectin and all-cause mortality based on body composition in haemodialysis patients. The trunk and total body fat were determined. The patients were divided into two groups based on serum adiponectin levels. In Kaplan–Meier analysis, the higher adiponectin group showed higher mortality than the lower adiponectin group. Serum adiponectin showed an inverse correlation with the percentage of truncal fat, suggesting serum adiponectin as an inverse marker for adiposity in haemodialysis patients. However, even after adjustment for other factors, multivariate Cox proportional hazards analysis identified higher serum adiponectin as an independent factor positively associated with higher mortality in haemodialysis patients. This association held true even when the total fat mass was replaced with the percentage of truncal fat, and when total fat mass and percentage of truncal fat were simultaneously included. Thus, we found a paradoxical association of higher serum adiponectin with higher all-cause mortality in Japanese haemodialysis patients, independent of adiposity. |
format | Online Article Text |
id | pubmed-6168594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61685942018-10-05 Paradoxical positive association of serum adiponectin with all-cause mortality based on body composition in Japanese haemodialysis patients Machiba, Yuri Inaba, Masaaki Mori, Katsuhito Kurajoh, Masafumi Nishide, Kozo Norimine, Kyoko Yamakawa, Tomoyuki Shoji, Shigeichi Okuno, Senji Sci Rep Article We have previously reported a paradoxical association of serum adiponectin with aortic calcification in haemodialysis patients. Because serum adiponectin is a nutritional marker, we examined the association between serum adiponectin and all-cause mortality based on body composition in haemodialysis patients. The trunk and total body fat were determined. The patients were divided into two groups based on serum adiponectin levels. In Kaplan–Meier analysis, the higher adiponectin group showed higher mortality than the lower adiponectin group. Serum adiponectin showed an inverse correlation with the percentage of truncal fat, suggesting serum adiponectin as an inverse marker for adiposity in haemodialysis patients. However, even after adjustment for other factors, multivariate Cox proportional hazards analysis identified higher serum adiponectin as an independent factor positively associated with higher mortality in haemodialysis patients. This association held true even when the total fat mass was replaced with the percentage of truncal fat, and when total fat mass and percentage of truncal fat were simultaneously included. Thus, we found a paradoxical association of higher serum adiponectin with higher all-cause mortality in Japanese haemodialysis patients, independent of adiposity. Nature Publishing Group UK 2018-10-02 /pmc/articles/PMC6168594/ /pubmed/30279489 http://dx.doi.org/10.1038/s41598-018-33011-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Machiba, Yuri Inaba, Masaaki Mori, Katsuhito Kurajoh, Masafumi Nishide, Kozo Norimine, Kyoko Yamakawa, Tomoyuki Shoji, Shigeichi Okuno, Senji Paradoxical positive association of serum adiponectin with all-cause mortality based on body composition in Japanese haemodialysis patients |
title | Paradoxical positive association of serum adiponectin with all-cause mortality based on body composition in Japanese haemodialysis patients |
title_full | Paradoxical positive association of serum adiponectin with all-cause mortality based on body composition in Japanese haemodialysis patients |
title_fullStr | Paradoxical positive association of serum adiponectin with all-cause mortality based on body composition in Japanese haemodialysis patients |
title_full_unstemmed | Paradoxical positive association of serum adiponectin with all-cause mortality based on body composition in Japanese haemodialysis patients |
title_short | Paradoxical positive association of serum adiponectin with all-cause mortality based on body composition in Japanese haemodialysis patients |
title_sort | paradoxical positive association of serum adiponectin with all-cause mortality based on body composition in japanese haemodialysis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168594/ https://www.ncbi.nlm.nih.gov/pubmed/30279489 http://dx.doi.org/10.1038/s41598-018-33011-y |
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