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Motor Sequence Learning Is Associated With Hippocampal Subfield Volume in Humans With Medial Temporal Lobe Epilepsy

Objectives: Medial temporal lobe epilepsy (mTLE) is characterized by decreased hippocampal volume, which results in motor memory consolidation impairments. However, the extent to which motor memory acquisition are affected in humans with mTLE remains poorly understood. We therefore examined the exte...

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Autores principales: Long, Jinyi, Feng, Yanyun, Liao, HongPeng, Zhou, Quan, Urbin, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168622/
https://www.ncbi.nlm.nih.gov/pubmed/30319375
http://dx.doi.org/10.3389/fnhum.2018.00367
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author Long, Jinyi
Feng, Yanyun
Liao, HongPeng
Zhou, Quan
Urbin, M. A.
author_facet Long, Jinyi
Feng, Yanyun
Liao, HongPeng
Zhou, Quan
Urbin, M. A.
author_sort Long, Jinyi
collection PubMed
description Objectives: Medial temporal lobe epilepsy (mTLE) is characterized by decreased hippocampal volume, which results in motor memory consolidation impairments. However, the extent to which motor memory acquisition are affected in humans with mTLE remains poorly understood. We therefore examined the extent to which learning of a motor tapping sequence task is affected by mTLE. Methods: MRI volumetric analysis was performed using a T1-weighted three-dimensional gradient echo sequence in 15 patients with right mTLE and 15 control subjects. Subjects trained on a motor sequence tapping task with the left hand in right mTLE and non-dominant hand in neurologically-intact controls. Results: The number of correct sequences performed by the mTLE patient group increased after training, albeit to a lesser extent than the control group. Although hippocampal subfield volume was reduced in mTLE relative to controls, no differences were observed in the volumes of other brain areas including thalamus, caudate, putamen and amygdala. Correlations between hippocampal subfield volumes and the change in pre- to post-training performance indicated that the volume of hippocampal subfield CA2–3 was associated with motor sequence learning in patients with mTLE. Significance: These results provide evidence that individuals with mTLE exhibit learning on a motor sequence task. Learning is linked to the volume of hippocampal subfield CA2–3, supporting a role of the hippocampus in motor memory acquisition. Highlights: -. Humans with mTLE exhibit learning on a motor tapping sequence task but not to the same extent as neurologically-intact controls. -. Hippocampal subfield volumes are significantly reduced after mTLE. Surrounding brain area volumes do not show abnormalities. -. Hippocampal subfield CA2–3 volume is associated with motor sequence learning in humans with mTLE.
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spelling pubmed-61686222018-10-12 Motor Sequence Learning Is Associated With Hippocampal Subfield Volume in Humans With Medial Temporal Lobe Epilepsy Long, Jinyi Feng, Yanyun Liao, HongPeng Zhou, Quan Urbin, M. A. Front Hum Neurosci Neuroscience Objectives: Medial temporal lobe epilepsy (mTLE) is characterized by decreased hippocampal volume, which results in motor memory consolidation impairments. However, the extent to which motor memory acquisition are affected in humans with mTLE remains poorly understood. We therefore examined the extent to which learning of a motor tapping sequence task is affected by mTLE. Methods: MRI volumetric analysis was performed using a T1-weighted three-dimensional gradient echo sequence in 15 patients with right mTLE and 15 control subjects. Subjects trained on a motor sequence tapping task with the left hand in right mTLE and non-dominant hand in neurologically-intact controls. Results: The number of correct sequences performed by the mTLE patient group increased after training, albeit to a lesser extent than the control group. Although hippocampal subfield volume was reduced in mTLE relative to controls, no differences were observed in the volumes of other brain areas including thalamus, caudate, putamen and amygdala. Correlations between hippocampal subfield volumes and the change in pre- to post-training performance indicated that the volume of hippocampal subfield CA2–3 was associated with motor sequence learning in patients with mTLE. Significance: These results provide evidence that individuals with mTLE exhibit learning on a motor sequence task. Learning is linked to the volume of hippocampal subfield CA2–3, supporting a role of the hippocampus in motor memory acquisition. Highlights: -. Humans with mTLE exhibit learning on a motor tapping sequence task but not to the same extent as neurologically-intact controls. -. Hippocampal subfield volumes are significantly reduced after mTLE. Surrounding brain area volumes do not show abnormalities. -. Hippocampal subfield CA2–3 volume is associated with motor sequence learning in humans with mTLE. Frontiers Media S.A. 2018-09-26 /pmc/articles/PMC6168622/ /pubmed/30319375 http://dx.doi.org/10.3389/fnhum.2018.00367 Text en Copyright © 2018 Long, Feng, Liao, Zhou and Urbin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Long, Jinyi
Feng, Yanyun
Liao, HongPeng
Zhou, Quan
Urbin, M. A.
Motor Sequence Learning Is Associated With Hippocampal Subfield Volume in Humans With Medial Temporal Lobe Epilepsy
title Motor Sequence Learning Is Associated With Hippocampal Subfield Volume in Humans With Medial Temporal Lobe Epilepsy
title_full Motor Sequence Learning Is Associated With Hippocampal Subfield Volume in Humans With Medial Temporal Lobe Epilepsy
title_fullStr Motor Sequence Learning Is Associated With Hippocampal Subfield Volume in Humans With Medial Temporal Lobe Epilepsy
title_full_unstemmed Motor Sequence Learning Is Associated With Hippocampal Subfield Volume in Humans With Medial Temporal Lobe Epilepsy
title_short Motor Sequence Learning Is Associated With Hippocampal Subfield Volume in Humans With Medial Temporal Lobe Epilepsy
title_sort motor sequence learning is associated with hippocampal subfield volume in humans with medial temporal lobe epilepsy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168622/
https://www.ncbi.nlm.nih.gov/pubmed/30319375
http://dx.doi.org/10.3389/fnhum.2018.00367
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