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Immunotolerant p50/NFκB Signaling and Attenuated Hepatic IFNβ Expression Increases Neonatal Sensitivity to Endotoxemia

Sepsis is a major cause of neonatal morbidity and mortality. The current paradigm suggests that neonatal susceptibility to infection is explained by an innate immune response that is functionally immature. Recent studies in adults have questioned a therapeutic role for IFNβ in sepsis; however, the r...

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Detalles Bibliográficos
Autores principales:	McKenna, Sarah, Burey, Taylor, Sandoval, Jeryl, Nguyen, Leanna, Castro, Odalis, Gudipati, Suma, Gonzalez, Jazmin, El Kasmi, Karim C., Wright, Clyde J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168645/ https://www.ncbi.nlm.nih.gov/pubmed/30319651 http://dx.doi.org/10.3389/fimmu.2018.02210

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