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PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer that is typically diagnosed at a later stage with metastases and is difficult to treat. Therefore, investigating the mechanism of PDAC initiation is important to aid early‐stage cancer detection. PRDM14 is a transcription fac...

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Autores principales: Moriya, Chiharu, Imai, Kohzoh, Taniguchi, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168686/
https://www.ncbi.nlm.nih.gov/pubmed/30338223
http://dx.doi.org/10.1002/2211-5463.12519
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author Moriya, Chiharu
Imai, Kohzoh
Taniguchi, Hiroaki
author_facet Moriya, Chiharu
Imai, Kohzoh
Taniguchi, Hiroaki
author_sort Moriya, Chiharu
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer that is typically diagnosed at a later stage with metastases and is difficult to treat. Therefore, investigating the mechanism of PDAC initiation is important to aid early‐stage cancer detection. PRDM14 is a transcription factor that maintains pluripotency in embryonic stem cells and is overexpressed in several cancers. We previously reported that PRDM14 is overexpressed and regulates cancer stem‐like phenotypes in PDAC, and herein, we assess whether PRDM14 expression increases prior to tumorigenesis. Through immunohistochemistry analyses of clinical tissues, we detected PRDM14‐positive cells in precursor pancreatic intraepithelial neoplasia and chronic pancreatitis, which is a risk factor for PDAC, lesions. PRDM14 staining in chronic pancreatitis was as high as that in PDAC and cancer adjacent tissues. We induced pancreatitis in mouse models by cerulein injection, and observed that PRDM14 expression increased in chronic pancreatitis models but not in control or acute pancreatitis mice. Moreover, cerulein treatment increased PRDM14 expression in PK‐1 and AsPC‐1 pancreatic cancer cell lines. Our results suggest that inflammation increases the expression of PRDM14, which regulates cancer stem‐like phenotypes, and this occurs prior to PDAC initiation and progression.
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spelling pubmed-61686862018-10-18 PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer Moriya, Chiharu Imai, Kohzoh Taniguchi, Hiroaki FEBS Open Bio Research Articles Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer that is typically diagnosed at a later stage with metastases and is difficult to treat. Therefore, investigating the mechanism of PDAC initiation is important to aid early‐stage cancer detection. PRDM14 is a transcription factor that maintains pluripotency in embryonic stem cells and is overexpressed in several cancers. We previously reported that PRDM14 is overexpressed and regulates cancer stem‐like phenotypes in PDAC, and herein, we assess whether PRDM14 expression increases prior to tumorigenesis. Through immunohistochemistry analyses of clinical tissues, we detected PRDM14‐positive cells in precursor pancreatic intraepithelial neoplasia and chronic pancreatitis, which is a risk factor for PDAC, lesions. PRDM14 staining in chronic pancreatitis was as high as that in PDAC and cancer adjacent tissues. We induced pancreatitis in mouse models by cerulein injection, and observed that PRDM14 expression increased in chronic pancreatitis models but not in control or acute pancreatitis mice. Moreover, cerulein treatment increased PRDM14 expression in PK‐1 and AsPC‐1 pancreatic cancer cell lines. Our results suggest that inflammation increases the expression of PRDM14, which regulates cancer stem‐like phenotypes, and this occurs prior to PDAC initiation and progression. John Wiley and Sons Inc. 2018-09-17 /pmc/articles/PMC6168686/ /pubmed/30338223 http://dx.doi.org/10.1002/2211-5463.12519 Text en © 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Moriya, Chiharu
Imai, Kohzoh
Taniguchi, Hiroaki
PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
title PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
title_full PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
title_fullStr PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
title_full_unstemmed PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
title_short PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
title_sort prdm14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168686/
https://www.ncbi.nlm.nih.gov/pubmed/30338223
http://dx.doi.org/10.1002/2211-5463.12519
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