Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity

We herein present behavioral data regarding whether COA-Cl, a novel adenosine-like nucleic acid analog that promotes angiogenesis and features neuroprotective roles, improves cognitive and behavioral deficits in a murine model for Alzheimer׳s disease (AD). COA-Cl induced significant spatial memory i...

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Autores principales: Kishimoto, Yasushi, Tsukamoto, Ikuko, Nishigawa, Atsuko, Nishimoto, Akiko, Kirino, Yutaka, Kato, Yoshihisa, Konishi, Ryoji, Maruyama, Tokumi, Sakakibara, Norikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168792/
https://www.ncbi.nlm.nih.gov/pubmed/30294639
http://dx.doi.org/10.1016/j.dib.2018.09.044
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author Kishimoto, Yasushi
Tsukamoto, Ikuko
Nishigawa, Atsuko
Nishimoto, Akiko
Kirino, Yutaka
Kato, Yoshihisa
Konishi, Ryoji
Maruyama, Tokumi
Sakakibara, Norikazu
author_facet Kishimoto, Yasushi
Tsukamoto, Ikuko
Nishigawa, Atsuko
Nishimoto, Akiko
Kirino, Yutaka
Kato, Yoshihisa
Konishi, Ryoji
Maruyama, Tokumi
Sakakibara, Norikazu
author_sort Kishimoto, Yasushi
collection PubMed
description We herein present behavioral data regarding whether COA-Cl, a novel adenosine-like nucleic acid analog that promotes angiogenesis and features neuroprotective roles, improves cognitive and behavioral deficits in a murine model for Alzheimer׳s disease (AD). COA-Cl induced significant spatial memory improvement in the amyloid precursor protein/presenilin 2 double-transgenic mouse model of AD (PS2Tg2576 mice). Correspondingly, non-spatial novel object cognition test performance also significantly improved in COA-Cl-treated PS2Tg2576 mice; however, these mice demonstrated no significant changes in physical activity or motor performance. COA-Cl did not change the spontaneous activities and cognitive ability in the wild-type mice.
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spelling pubmed-61687922018-10-05 Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity Kishimoto, Yasushi Tsukamoto, Ikuko Nishigawa, Atsuko Nishimoto, Akiko Kirino, Yutaka Kato, Yoshihisa Konishi, Ryoji Maruyama, Tokumi Sakakibara, Norikazu Data Brief Neuroscience We herein present behavioral data regarding whether COA-Cl, a novel adenosine-like nucleic acid analog that promotes angiogenesis and features neuroprotective roles, improves cognitive and behavioral deficits in a murine model for Alzheimer׳s disease (AD). COA-Cl induced significant spatial memory improvement in the amyloid precursor protein/presenilin 2 double-transgenic mouse model of AD (PS2Tg2576 mice). Correspondingly, non-spatial novel object cognition test performance also significantly improved in COA-Cl-treated PS2Tg2576 mice; however, these mice demonstrated no significant changes in physical activity or motor performance. COA-Cl did not change the spontaneous activities and cognitive ability in the wild-type mice. Elsevier 2018-09-19 /pmc/articles/PMC6168792/ /pubmed/30294639 http://dx.doi.org/10.1016/j.dib.2018.09.044 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Neuroscience
Kishimoto, Yasushi
Tsukamoto, Ikuko
Nishigawa, Atsuko
Nishimoto, Akiko
Kirino, Yutaka
Kato, Yoshihisa
Konishi, Ryoji
Maruyama, Tokumi
Sakakibara, Norikazu
Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity
title Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity
title_full Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity
title_fullStr Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity
title_full_unstemmed Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity
title_short Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity
title_sort data on coa-cl administration to the app/ps2 double-transgenic mouse model of alzheimer׳s disease: improved hippocampus-dependent learning and unchanged spontaneous physical activity
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168792/
https://www.ncbi.nlm.nih.gov/pubmed/30294639
http://dx.doi.org/10.1016/j.dib.2018.09.044
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