Clinical evidence on haemodiafiltration

Haemodiafiltration (HDF) combines diffusive and convective solute removal in a single treatment session. HDF provides a greater removal of higher molecular weight uraemic retention solutes than conventional high-flux haemodialysis (HD). Recently completed randomized clinical trials suggest better pa...

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Detalles Bibliográficos
Autores principales: Blankestijn, Peter J, Grooteman, Muriel P, Nube, Menso J, Bots, Michiel L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168838/
https://www.ncbi.nlm.nih.gov/pubmed/30281128
http://dx.doi.org/10.1093/ndt/gfy218
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author Blankestijn, Peter J
Grooteman, Muriel P
Nube, Menso J
Bots, Michiel L
author_facet Blankestijn, Peter J
Grooteman, Muriel P
Nube, Menso J
Bots, Michiel L
author_sort Blankestijn, Peter J
collection PubMed
description Haemodiafiltration (HDF) combines diffusive and convective solute removal in a single treatment session. HDF provides a greater removal of higher molecular weight uraemic retention solutes than conventional high-flux haemodialysis (HD). Recently completed randomized clinical trials suggest better patient survival with online HDF. The treatment is mainly used in Europe and Japan. This review gives a brief overview of the presently available evidence of the effects of HDF on clinical end points, it speculates on possible mechanisms of a beneficial effect of HDF as compared with standard HD and ends with some perspectives for the future.
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spelling pubmed-61688382018-10-09 Clinical evidence on haemodiafiltration Blankestijn, Peter J Grooteman, Muriel P Nube, Menso J Bots, Michiel L Nephrol Dial Transplant Reviews Haemodiafiltration (HDF) combines diffusive and convective solute removal in a single treatment session. HDF provides a greater removal of higher molecular weight uraemic retention solutes than conventional high-flux haemodialysis (HD). Recently completed randomized clinical trials suggest better patient survival with online HDF. The treatment is mainly used in Europe and Japan. This review gives a brief overview of the presently available evidence of the effects of HDF on clinical end points, it speculates on possible mechanisms of a beneficial effect of HDF as compared with standard HD and ends with some perspectives for the future. Oxford University Press 2018-10 2018-10-03 /pmc/articles/PMC6168838/ /pubmed/30281128 http://dx.doi.org/10.1093/ndt/gfy218 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Reviews
Blankestijn, Peter J
Grooteman, Muriel P
Nube, Menso J
Bots, Michiel L
Clinical evidence on haemodiafiltration
title Clinical evidence on haemodiafiltration
title_full Clinical evidence on haemodiafiltration
title_fullStr Clinical evidence on haemodiafiltration
title_full_unstemmed Clinical evidence on haemodiafiltration
title_short Clinical evidence on haemodiafiltration
title_sort clinical evidence on haemodiafiltration
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168838/
https://www.ncbi.nlm.nih.gov/pubmed/30281128
http://dx.doi.org/10.1093/ndt/gfy218
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