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Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment

The cycloundecapeptide cyclosporin A (CsA) was first isolated from the insect-pathogenic fungus Tolypocladium inflatum for its antifungal activity and later developed as an immunosuppressant drug. However, the full biosynthetic mechanism of CsA remains unknown and has puzzled researchers for decades...

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Detalles Bibliográficos
Autores principales:	Yang, Xiuqing, Feng, Peng, Yin, Ying, Bushley, Kathryn, Spatafora, Joseph W., Wang, Chengshu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168864/ https://www.ncbi.nlm.nih.gov/pubmed/30279281 http://dx.doi.org/10.1128/mBio.01211-18

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