Cargando…

Checkpoint Inhibition in Myeloma: Opportunities and Challenges

Despite major improvements in the treatment landscape, most multiple myeloma (MM) patients eventually succumb to the underlying malignancy. Immunotherapy represents an attractive strategy to achieve durable remissions due to its specificity and capacity for long term memory. Activation of immune cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Costa, Federica, Das, Rituparna, Kini Bailur, Jithendra, Dhodapkar, Kavita, Dhodapkar, Madhav V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168958/ https://www.ncbi.nlm.nih.gov/pubmed/30319648 http://dx.doi.org/10.3389/fimmu.2018.02204

Ejemplares similares

Co-evolution of Immune Response in Multiple Myeloma: Implications for Immune Prevention
por: McCachren, Samuel S., et al.
Publicado: (2021)

Moving Immunoprevention Beyond Virally Mediated Malignancies: Do We Need to Link It to Early Detection?
por: Dhodapkar, Madhav V., et al.
Publicado: (2019)

Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade
por: Dhodapkar, Kavita M.
Publicado: (2018)

Distinct immunologic changes in vivo following combination versus individual PD-1 or CTLA-4 checkpoint blockade in human cancer
por: Dhodapkar, Kavita, et al.
Publicado: (2014)

SOX2-specific adaptive immunity and response to immunotherapy in non-small cell lung cancer
por: Dhodapkar, Kavita M, et al.
Publicado: (2013)

Antitumor Monoclonal Antibodies Enhance Cross-Presentation of Cellular Antigens and the Generation of Myeloma-specific Killer T Cells by Dendritic Cells
por: Dhodapkar, Kavita M., et al.
Publicado: (2002)

Enhancement of clonogenicity of human multiple myeloma by dendritic cells
por: Kukreja, Anjli, et al.
Publicado: (2006)

Risk-associated alterations in marrow T cells in pediatric leukemia
por: Bailur, Jithendra Kini, et al.
Publicado: (2020)

Natural Killer T Cells in Cancer Immunotherapy
por: Nair, Shiny, et al.
Publicado: (2017)

A Reversible Defect in Natural Killer T Cell Function Characterizes the Progression of Premalignant to Malignant Multiple Myeloma
por: Dhodapkar, Madhav V., et al.
Publicado: (2003)

Editorial: HIV and Cancer Immunotherapy: Similar Challenges and Converging Approaches
por: Paiardini, Mirko, et al.
Publicado: (2020)

Prognostic impact of high levels of circulating plasmacytoid dendritic cells in breast cancer
por: Kini Bailur, Jithendra, et al.
Publicado: (2016)

Game of Bones: How Myeloma Manipulates Its Microenvironment
por: Moser-Katz, Tyler, et al.
Publicado: (2021)

Presence of circulating Her-2 reactive CD8 T cells is associated with a lower frequency of MDSCs and better survival in elderly breast cancer patients
por: Kini Bailur, Jithendra, et al.
Publicado: (2014)

Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients
por: Bailur, Jithendra Kini, et al.
Publicado: (2015)

Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients
por: Bailur, Jithendra Kini, et al.
Publicado: (2015)

A survey-wide association study to identify youth-specific correlates of major depressive episodes
por: Dhodapkar, Rahul Madhav
Publicado: (2020)

Tissue resident memory T cells create genetically distinct immune microenvironments within melanoma metastasis
por: Dhodapkar, Kavita, et al.
Publicado: (2015)

Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges
por: Pacella, Ilenia, et al.
Publicado: (2019)

Selective blockade of the inhibitory Fcγ receptor (FcγRIIB) in human dendritic cells and monocytes induces a type I interferon response program
por: Dhodapkar, Kavita M., et al.
Publicado: (2007)

Selective blockade of the inhibitory Fcγ receptor (FcγRIIB) in human dendritic cells and monocytes induces a type I interferon response program
por: Dhodapkar, Kavita M., et al.
Publicado: (2007)

Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
por: Moreno, Alberto, et al.
Publicado: (2023)

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells
por: Dhodapkar, Madhav V., et al.
Publicado: (2001)

Determinants of Neutralizing Antibody Response After SARS CoV-2 Vaccination in Patients With Myeloma
por: Nooka, Ajay K., et al.
Publicado: (2022)

Vigorous Premalignancy-specific Effector T Cell Response in the Bone Marrow of Patients with Monoclonal Gammopathy
por: Dhodapkar, Madhav V., et al.
Publicado: (2003)

Downregulation of PA28α induces proteasome remodeling and results in resistance to proteasome inhibitors in multiple myeloma
por: Gu, Yanyan, et al.
Publicado: (2020)

Epstein-Barr Virus: An Infrequent Pathogen of Acute Undifferentiated Febrile Illness From a Tertiary Care Hospital in Southern India
por: Dhodapkar, Rahul, et al.
Publicado: (2021)

Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty
por: Bailur, Jithendra Kini, et al.
Publicado: (2017)

Regulation of antigen-specific T cell infiltration and spatial architecture in multiple myeloma and premalignancy
por: Robinson, M. Hope, et al.
Publicado: (2023)

Elotuzumab monotherapy in patients with smouldering multiple myeloma: a phase 2 study
por: Jagannath, Sundar, et al.
Publicado: (2018)

Plastic waste recycling: existing Indian scenario and future opportunities
por: Shanker, R., et al.
Publicado: (2022)

Opportunities and Challenges in Democratizing Immunology Datasets
por: Bhattacharya, Sanchita, et al.
Publicado: (2021)

Syphilis vaccine: challenges, controversies and opportunities
por: Ávila-Nieto, Carlos, et al.
Publicado: (2023)

Bystander Memory T Cells and IMiD/Checkpoint Therapy in Multiple Myeloma: A Dangerous Tango?
por: Sponaas, Anne Marit, et al.
Publicado: (2021)

Immune profiling of breast cancer patients: relationship between tumour antigen T cell responses with suppressor and effector leukocyte populations
por: Janssen, Nicole, et al.
Publicado: (2015)

Tandem high-dose influenza vaccination is associated with more durable serologic immunity in patients with plasma cell dyscrasias
por: Branagan, Andrew R., et al.
Publicado: (2021)

Microenvironment-dependent growth of pre-neoplastic and malignant plasma cells in humanized mice
por: Das, Rituparna, et al.
Publicado: (2016)

T-Cell-Based Immunotherapy for Osteosarcoma: Challenges and Opportunities
por: Wang, Zhan, et al.
Publicado: (2016)

The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities
por: Bayati, Fatemeh, et al.
Publicado: (2021)

T cell immunotherapy for cervical cancer: challenges and opportunities
por: Yu, Lingfeng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bqleud2evb4stefb059j44cacp