Lymphatic endothelial cells promote productive and latent HIV infection in resting CD4+ T cells

BACKGROUND: An HIV cure has not yet been achieved because latent viral reservoirs persist, particularly in resting CD4+ T lymphocytes. In vitro, it is difficult to infect resting CD4+ T cells with HIV-1, but infections readily occur in vivo. Endothelial cells (EC) line the lymphatic vessels in the l...

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Detalles Bibliográficos
Autores principales: Schilthuis, Meghan, Verkaik, Seth, Walhof, Mackenzie, Philipose, Andrew, Harlow, Olivia, Kamp, Derrick, Kim, Bo Ram, Shen, Anding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169068/
https://www.ncbi.nlm.nih.gov/pubmed/30285810
http://dx.doi.org/10.1186/s12985-018-1068-6

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