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The Application of a Desktop NMR Spectrometer in Drug Analysis

A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate t...

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Detalles Bibliográficos
Autores principales: Zhong, Yonghong, Huang, Kejian, Luo, Qiulian, Yao, Suzhi, Liu, Xiaofeng, Yang, Ning, Lin, Cuiwu, Luo, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169242/
https://www.ncbi.nlm.nih.gov/pubmed/30327671
http://dx.doi.org/10.1155/2018/3104569
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author Zhong, Yonghong
Huang, Kejian
Luo, Qiulian
Yao, Suzhi
Liu, Xiaofeng
Yang, Ning
Lin, Cuiwu
Luo, Xuan
author_facet Zhong, Yonghong
Huang, Kejian
Luo, Qiulian
Yao, Suzhi
Liu, Xiaofeng
Yang, Ning
Lin, Cuiwu
Luo, Xuan
author_sort Zhong, Yonghong
collection PubMed
description A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate the feasibility and reliability of the methods. First, 1-D and 2-D NMR data for these 12 drugs and their derivatives were obtained in detail using a 600-MHz NMR spectrometer to create a data library. Next, some of these 12 drugs were analyzed using a Picospin 80 MHz desktop NMR spectrometer to set up the analytical procedure and method. With the procedure and method established, real case samples were analyzed and the data were compared to those obtained by a standard method. The results indicate that the desktop NMR spectrometer is a reliable and promising approach that can be used in criminology to quickly identify whether or not samples contain illegal drugs.
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spelling pubmed-61692422018-10-16 The Application of a Desktop NMR Spectrometer in Drug Analysis Zhong, Yonghong Huang, Kejian Luo, Qiulian Yao, Suzhi Liu, Xiaofeng Yang, Ning Lin, Cuiwu Luo, Xuan Int J Anal Chem Research Article A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate the feasibility and reliability of the methods. First, 1-D and 2-D NMR data for these 12 drugs and their derivatives were obtained in detail using a 600-MHz NMR spectrometer to create a data library. Next, some of these 12 drugs were analyzed using a Picospin 80 MHz desktop NMR spectrometer to set up the analytical procedure and method. With the procedure and method established, real case samples were analyzed and the data were compared to those obtained by a standard method. The results indicate that the desktop NMR spectrometer is a reliable and promising approach that can be used in criminology to quickly identify whether or not samples contain illegal drugs. Hindawi 2018-09-19 /pmc/articles/PMC6169242/ /pubmed/30327671 http://dx.doi.org/10.1155/2018/3104569 Text en Copyright © 2018 Yonghong Zhong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhong, Yonghong
Huang, Kejian
Luo, Qiulian
Yao, Suzhi
Liu, Xiaofeng
Yang, Ning
Lin, Cuiwu
Luo, Xuan
The Application of a Desktop NMR Spectrometer in Drug Analysis
title The Application of a Desktop NMR Spectrometer in Drug Analysis
title_full The Application of a Desktop NMR Spectrometer in Drug Analysis
title_fullStr The Application of a Desktop NMR Spectrometer in Drug Analysis
title_full_unstemmed The Application of a Desktop NMR Spectrometer in Drug Analysis
title_short The Application of a Desktop NMR Spectrometer in Drug Analysis
title_sort application of a desktop nmr spectrometer in drug analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169242/
https://www.ncbi.nlm.nih.gov/pubmed/30327671
http://dx.doi.org/10.1155/2018/3104569
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