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The Application of a Desktop NMR Spectrometer in Drug Analysis
A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169242/ https://www.ncbi.nlm.nih.gov/pubmed/30327671 http://dx.doi.org/10.1155/2018/3104569 |
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author | Zhong, Yonghong Huang, Kejian Luo, Qiulian Yao, Suzhi Liu, Xiaofeng Yang, Ning Lin, Cuiwu Luo, Xuan |
author_facet | Zhong, Yonghong Huang, Kejian Luo, Qiulian Yao, Suzhi Liu, Xiaofeng Yang, Ning Lin, Cuiwu Luo, Xuan |
author_sort | Zhong, Yonghong |
collection | PubMed |
description | A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate the feasibility and reliability of the methods. First, 1-D and 2-D NMR data for these 12 drugs and their derivatives were obtained in detail using a 600-MHz NMR spectrometer to create a data library. Next, some of these 12 drugs were analyzed using a Picospin 80 MHz desktop NMR spectrometer to set up the analytical procedure and method. With the procedure and method established, real case samples were analyzed and the data were compared to those obtained by a standard method. The results indicate that the desktop NMR spectrometer is a reliable and promising approach that can be used in criminology to quickly identify whether or not samples contain illegal drugs. |
format | Online Article Text |
id | pubmed-6169242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61692422018-10-16 The Application of a Desktop NMR Spectrometer in Drug Analysis Zhong, Yonghong Huang, Kejian Luo, Qiulian Yao, Suzhi Liu, Xiaofeng Yang, Ning Lin, Cuiwu Luo, Xuan Int J Anal Chem Research Article A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate the feasibility and reliability of the methods. First, 1-D and 2-D NMR data for these 12 drugs and their derivatives were obtained in detail using a 600-MHz NMR spectrometer to create a data library. Next, some of these 12 drugs were analyzed using a Picospin 80 MHz desktop NMR spectrometer to set up the analytical procedure and method. With the procedure and method established, real case samples were analyzed and the data were compared to those obtained by a standard method. The results indicate that the desktop NMR spectrometer is a reliable and promising approach that can be used in criminology to quickly identify whether or not samples contain illegal drugs. Hindawi 2018-09-19 /pmc/articles/PMC6169242/ /pubmed/30327671 http://dx.doi.org/10.1155/2018/3104569 Text en Copyright © 2018 Yonghong Zhong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhong, Yonghong Huang, Kejian Luo, Qiulian Yao, Suzhi Liu, Xiaofeng Yang, Ning Lin, Cuiwu Luo, Xuan The Application of a Desktop NMR Spectrometer in Drug Analysis |
title | The Application of a Desktop NMR Spectrometer in Drug Analysis |
title_full | The Application of a Desktop NMR Spectrometer in Drug Analysis |
title_fullStr | The Application of a Desktop NMR Spectrometer in Drug Analysis |
title_full_unstemmed | The Application of a Desktop NMR Spectrometer in Drug Analysis |
title_short | The Application of a Desktop NMR Spectrometer in Drug Analysis |
title_sort | application of a desktop nmr spectrometer in drug analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169242/ https://www.ncbi.nlm.nih.gov/pubmed/30327671 http://dx.doi.org/10.1155/2018/3104569 |
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